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Physalis peruviana calyces are used extensively in folk medicine. The crude ethanolic extract and some fractions of calyces were evaluated in order to explore antioxidant and anti-inflammatory activities. The anti-inflammatory activity was evaluated by the TPA-induced ear edema model. The antioxidant in vitro activity was measured by means of the superoxide and nitric oxide scavenging activity of the extracts and fractions. The butanolic fraction was found to be promising due to its anti-inflammatory and antioxidant activities.Therefore, a bio-assay guided approach was employed to isolate and identify rutin (1) and nicotoflorin (2) from their NMR spectroscopic and MS data. The identification of rutin in calyces of P. peruviana supports the possible use of this waste material for phytotherapeutic, nutraceutical and cosmetic preparations.

The thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of triclosan (TS) were calculated from solubility values obtained at the temperature interval from (293.15 to 313.15) K. TS solubility was determined in ethanol (EtOH), octanol (ROH), isopropyl myristate (IPM), chloroform (CLF), and heptane (HPT) as pure solvents. The excess Gibbs energy and the activity coefficients of the solutes were also calculated. The TS solubilities were higher in EtOH and CLF with respect to those obtained in ROH, IPM, and HPT. In addition, the thermodynamic quantities relative to the transfer process of this drug from HPT to the other organic solvents were also calculated to estimate the hydrogen bonding contributions.

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<span style="font-family: Verdana; font-size: small;"><em>Physalis peruviana</em> es una especie andina, cuyos frutos además de ser usados como alimento, son empleados en la medicina tradicional para el tratamiento de la diabetes mellitus. Además, estudios farmacológicos previos en ratas Wistar han demostrado actividad antidiabética de extractos de frutos de <em>P. peruviana</em>. Con el fin de profundizar en el modo de acción de la actividad antidiabética de los frutos de <em>P. peruviana</em>, en la presente investigación se determinó la concentración inhibitoria 50 (CI₅₀) del extracto crudo de frutos de <em>P. peruviana</em>, sobre las enzimas alfa glucosidasa obtenida de <em>S. cerevisiae</em> y de polvo intestinal de rata, maltasa y alfa amilasa. El comportamiento cinético del extracto sobre cada una de las enzimas también fue investigado y la constante enzimática (Km) y la velocidad máxima (Vmax) fueron determinadas. El extracto de frutos de <em>P. peruviana</em>, mostró diferentes valores de CI₅₀ para alfa glucosidasa obtenida de <em>S. cerevisiae</em> y para la obtenida de polvo intestinal de rata, sugiriendo una mayor afinidad por la enzima de origen mamífero (4114,7 and 3552,7 µg/mL, respectivamente). Para maltasa la CI₅₀ fue cercana a la obtenida para alfa glucosidasa (4191,0 µg/mL), mientras para alfa amilasa, el extracto presentó la mayor inhibición (CI₅₀: 619,9 g/mL). Respecto al comportamiento cinético, el extracto mostró inhibición de tipo competitiva sobre alfa glucosidasa y maltasa y no competitiva sobre alfa amilasa. Los resultados sugieren que la inhibición de carbohidrasas intestinales es uno de los modos de acción de los frutos de <em>P. peruviana</em> como agente antidiabético.</span>

Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of solute-solvent interactions.Uniterms: Ibuprofen. Solubility. Transfer. Solution thermodynamics. Organic solvents.As funções termodinâmicas, energia de Gibbs, entalpia e entropia dos processos de solução de ibuprofeno (IBP) em acetona e em diclorometano (DCM) foram calculadas a partir dos valores de solubilidade, obtidos em intervalos de temperatura de 293,15 K a 313,15 K. As funções termodinâmicas respectivas para os processos de mistura e solvatação e os coeficientes de atividade para o soluto também foram calculados. A solubilidade do IBP foi grande e semelhante em ambos os solventes, mas, maior em DCM do que em acetona. Em adição, as quantidades termodinâmicas relativas ao processo de transferência desse fármaco do cicloexano para os solventes orgânicos foram, também, calculadas com o objetivo de estimar as contribuições devidas às ligações de hidrogênio ou a outras interações dipolares. Os resultados foram discutidos nos termos das interações soluto-solvente.