Solubility of the Antimicrobial Agent Triclosan in Organic Solvents of Different Hydrogen Bonding Capabilities at Several Temperatures

Abstract

The thermodynamic functions of Gibbs energy, enthalpy, and entropy for the solution processes of triclosan (TS) were calculated from solubility values obtained at the temperature interval from (293.15 to 313.15) K. TS solubility was determined in ethanol (EtOH), octanol (ROH), isopropyl myristate (IPM), chloroform (CLF), and heptane (HPT) as pure solvents. The excess Gibbs energy and the activity coefficients of the solutes were also calculated. The TS solubilities were higher in EtOH and CLF with respect to those obtained in ROH, IPM, and HPT. In addition, the thermodynamic quantities relative to the transfer process of this drug from HPT to the other organic solvents were also calculated to estimate the hydrogen bonding contributions.

Solubility of triclosan and iodopropynyl butylcarbamate in pure alkanols at several temperatures

“…Therefore, solubility data in different solvents are very critical in industrial applications including purification. However, limited data are available on the solubility of triclosan and IPBC in solvents [8].…”

Solubility of some novel cyanopyridine derivatives

“…Where n is the number of experimental temperatures. 17 In present case, the value of T hm is obtained only 308K. The slope of the plot of ln x versus (1/T-1/308) gives the value of ∆H sol .…”

“…The endothermic effect may be due to strong interactions between compound and solvent molecules. 17,18 Whereas, positive ∆G sol values indicate that the dissolution process is spontaneous. The positive entropy indicates that dissolution process increases the randomness in solution.…”

Measurement and Correlation for Solubility of Some Pyrimidine Derivatives in Different Solvents

“…where is the number of experimental temperatures [13]. In the present case, the hm value obtained is 312.7505 K. The value of Δ sol was obtained from the slope of the plot of ln versus (1/ − 1/312.7505) as shown in Figure 5 for methanol, DMF, and CCl 4 .…”