In this work, uniform molybdenum disulfide (MoS2)/tungsten disulfide (WS2) quantum dots are synthesized by the combination of sonication and solvothermal treatment of bulk MoS2/WS2 at a mild temperature. The resulting products possess monolayer thickness with an average size about 3 nm. The highly exfoliated and defect‐rich structure renders these quantum dots plentiful active sites for the catalysis of hydrogen evolution reaction (HER). The MoS2 quantum dots exhibit a small HER overpotential of ≈120 mV and long‐term durability. Moreover, the strong fluorescence, good cell permeability, and low cytotoxicity make them promising and biocompatible probes for in vitro imaging. In addition, this work may provide an alternative facile approach to synthesize the quantum dots of transition metal dichalcogenides or other layered materials on a large scale.
Urea electrooxidation with favorable thermodynamic potential offers great promise for decoupling H2/O2 evolution from sluggish water splitting, and simultaneously mitigating the problem of urea‐rich water pollution. However, the intrinsically slow kinetics of the six‐electron transfer process impels one to explore efficient catalysts in order to enable widespread use of this catalytic system. In response, taking CoS2/MoS2 Schottky heterojunctions as the proof‐of‐concept paradigm, a catalytic model to modulate the surface charge distribution for synergistically facilitating the adsorption and fracture of chemical group in urea molecule is proposed and the mechanism of urea electrooxidation at the molecular level is elucidated. Based on density functional calculations, the self‐driven charge transfer across CoS2/MoS2 heterointerface would induce the formation of local electrophilic/nucleophilic region, which will intelligently adsorb electron‐donating/electron‐withdrawing groups in urea molecule, activate the chemical bonds, and thus trigger the decomposition of urea. Benefiting from the regulation of local charge distribution, the constructed Schottky catalyst of CoS2‐MoS2 exhibits superior urea catalytic activities with a potential of 1.29 V (only 0.06 V higher than the thermodynamic voltage of water decomposition) to attain 10 mA cm−2 as well as robust durability over 60 h. This innovational manipulation of charge distribution via Schottky heterojunction provides a model in exploring other highly efficient electrocatalysts.
Ascorbic acid (AA) is capable of inhibiting cancer cell growth by perturbing the normal redox state of cells and causing toxic effects through the generation of abundant reactive-oxygen species (ROS). However, the clinical utility of AA at a tolerable dosage is plagued by a relatively low in vivo efficacy. This study describes the development of a peroxidase-like composite nanoparticle for use in an AA-mediated therapeutic strategy. On the basis of a high-throughput, one-pot solvothermal approach, Fe3O4@C nanoparticles (NPs) were synthesized and then modified with folic acid (FA) on the surface. Particular focus is concentrated on the assessment of peroxidase-like catalytic activity by a chromogenic reaction in the presence of H2O2. The carbon shell of Fe3O4@C NPs contains partially graphitized carbon and thus facilitates electron transfer in the catalytic decomposition of H2O2, leading to the production of highly reactive hydroxyl radicals. Along with magnetic responsiveness and receptor-binding specificity, the intrinsic peroxidase-like catalytic activity of Fe3O4@C-FA NPs pronouncedly promotes AA-induced oxidative stress in cancer cells and optimizes the ROS-mediated antineoplastic efficacy of exogenous AA. In vitro experiments using human prostate cancer PC-3 cells demonstrate that Fe3O4@C-FA NPs serve as a peroxidase mimic to create hydroxyl radicals from endogenous H2O2 that is yielded in response to exogenous AA via an oxidative stress process. The usage of a dual agent leads to the enhanced cytotoxicity of PC-3 cells, and, because of the synergistic effect of NPs, the administrated dosage of AA is reduced markedly. However, because normal cells (HEK 293T cells) appear to have a higher capacity to cope with additionally generated ROS than cancer cells, the NP-AA combination shows little damage in this case, proving that selective killing of cancer cells could be achieved owing to preferential accumulation of ROS in cancer cells. A possible ROS-mediated mechanism is discussed to elucidate the pharmaceutical profile of the NP-AA agent. In general, this foundational study reveals that the peroxidase-like nanomaterials are applicable for modulating oxidative stress for the selective treatment of cancer cells by generating a high level of endogenous ROS.
Commercial deployment of lithium anodes has been severely impeded by the poor battery safety, unsatisfying cycling lifespan, and efficiency. Recently, building artificial interfacial layers over a lithium anode was regarded as an effective strategy to stabilize the electrode. However, the fabrications reported so far have mostly been conducted directly upon lithium foil, often requiring stringent reaction conditions with indispensable inert environment protection and highly specialized reagents due to the high reactivity of metallic lithium. Besides, the uneven lithium‐ion flux across the lithium surface should be more powerfully tailored via mighty interfacial layer materials. Herein, g‐C3N4 is employed as a Li+‐modulating material and a brand‐new autotransferable strategy to fabricate this interfacial layer for Li anodes without any inert atmosphere protection and limitation of chemical regents is developed. The g‐C3N4 film is filtrated on the separator in air using a common alcohol solution and then perfectly autotransferred to the lithium surface by electrolyte wetting during normal cell assembly. The abundant nitrogen species within g‐C3N4 nanosheets can form transient LiN bonds to powerfully stabilize the lithium‐ion flux and thus enable a CE over 99% for 900 cycles and smooth deposition at high current densities and capacities, surpassing most previous works.
Two-dimensional (2D) van der Waals ferromagnets carry the promise of ultimately miniature spintronics and information storage devices. Among the 2D ferromagnets, all inherit the magnetic ordering from their bulk ancestors. Here we report a 2D ferromagnetic semiconductor at room temperature, 2H-phase vanadium diselenide (VSe 2 ), which shows ferromagnetic at the 2D form only. This 2D ferromagnetic semiconductor manifests an enhanced magnetic ordering owing to structural anisotropy at the 2D limit.
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