Cancer therapy and fluorescence imaging using the active release of doxorubicin from MSPs/Ni-LDH folate targeting nanoparticles

Li, Dian; Zhang, Yuting; Yu, Meng; Guo, Jia; Chaudhary, Deeptangshu; Wang, Changchun

doi:10.1016/j.biomaterials.2013.06.046

Cited by 92 publications

(83 citation statements)

References 57 publications

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“…Ay et al and Li et al used the direct deposition method to synthesise magnetic metal oxide core@LDH shell nanocomposites by adsorbing LDH nanoparticles on the core surface. 48,49 Li et al also investigated the effect of post-aging temperature on the structure and physicochemical properties of the coreshell nanocomposites. With the temperature increasing from 100 to 160 1C, the LDH particles increased in size and crystallinity, and the morphology of LDH changed from flocculentlike to platelet-like shape.…”

Section: Direct Depositionmentioning

confidence: 99%

“…diclofenac, ibuprofen, and glucuronic acid), 14,56,58 anti-cancer drugs (e.g. doxorubicin, doxifluridine, and 5-fluorouracil), 41,42,49 and hepatitis B virus DNA vaccine. 46 Wang et al synthesised SiO 2 @LDH nanocomposites with an average diameter of 210 nm and mixed platelet morphology.…”

Section: Applications Of Core@ldh Nanocompositesmentioning

confidence: 99%

“…58 The magnetic drug delivery system concentrates the drug dosage at a target site with the aid of an external magnetic field, thus avoids nonspecific drug delivery, enhances the therapeutic effect and reduces the drug side effects. 59,60 The targeted delivery can also be achieved by conjugating antibody and other ligands on the LDH nanoparticles, 49,61 and will be described in detail in Section 6. Chen et al reported a typical vertically oriented SiO 2 @LDH core-shell nanocomposite synthesised by ultrasound-assisted coprecipitation (Fig.…”

Section: Applications Of Core@ldh Nanocompositesmentioning

confidence: 99%

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Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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a Layered double hydroxide (LDH)-based nanocomposites, constructed by interacting LDH nanoparticles with other nanomaterials (e.g. silica nanoparticles and magnetic nanoparticles) or polymeric molecules (e.g. proteins), are an emerging yet active area in healthcare, environmental remediation, energy conversion and storage.Combining advantages of each component in the structure and functions, hierarchical LDH-based nanocomposites have shown great potential in biomedicine, water purification, and energy storage and conversion.This feature article summarises the recent advances in LDH-based nanocomposites, focusing on their synthesis, structure, and application in drug delivery, bio-imaging, water purification, supercapacitors, and catalysis.

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Section: Direct Depositionmentioning

confidence: 99%

Section: Applications Of Core@ldh Nanocompositesmentioning

confidence: 99%

Section: Applications Of Core@ldh Nanocompositesmentioning

confidence: 99%

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Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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“…Fluorescence microscopy found that the designed nanospheres targeted the cancerous cells and were highly cytotoxic to the cancerous cells compared to normal HEK 293T cells. 96 …”

Section: Layered Double Hydroxides In Bioimagingmentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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“…In recent decades inorganic twodimensional nanomaterials and bio-nanohybrids based on clay minerals have been employed for targeted drug and gene delivery with controlled release [4,5], medical imaging and protein separation [6], which is an intensively developing field in nanomedicine, diagnostics and pharmaceutics [7,8]. Hierarchical nanoparticles with an external shell made of layered hydroxides and oxyhydroxides of metals are used as multifunctional bioactive agents for biomedical purposes [9,10] including anti-cancer therapy [11,12].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of charged protein residues on an inorganic nanosheet: Computer simulation of LDH interaction with ion channel

Цуканов¹,

Psakhie²

2016

AIP Conference Proceedings

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Abstract. Quasi-two-dimensional and hybrid nanomaterials based on layered double hydroxides (LDH), cationic clays, layered oxyhydroxides and hydroxides of metals possess large specific surface area and strong electrostatic properties with permanent or pH-dependent electric charge. Such nanomaterials may impact cellular electrostatics, changing the ion balance, pH and membrane potential. Selective ion adsorption/exchange may alter the transmembrane electrochemical gradient, disrupting potential-dependent cellular processes. Cellular proteins as a rule have charged residues which can be effectively adsorbed on the surface of layered hydroxide based nanomaterials. The aim of this study is to attempt to shed some light on the possibility and mechanisms of protein "adhesion" an LDH nanosheet and to propose a new direction in anticancer medicine, based on physical impact and strong electrostatics. An unbiased molecular dynamics simulation was performed and the combined process free energy estimation (COPFEE) approach was used.

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Cancer therapy and fluorescence imaging using the active release of doxorubicin from MSPs/Ni-LDH folate targeting nanoparticles

Cited by 92 publications

References 57 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Inorganic nanolayers: structure, preparation, and biomedical applications

Adsorption of charged protein residues on an inorganic nanosheet: Computer simulation of LDH interaction with ion channel

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Cancer therapy and fluorescence imaging using the active release of doxorubicin from MSPs/Ni-LDH folate targeting nanoparticles

Cited by 92 publications

References 57 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

Adsorption of charged protein residues on an inorganic nanosheet: Computer simulation of LDH interaction with ion channel

Contact Info

Product

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Inorganic nanolayers: structure, preparation, and biomedical applications