Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of coronavirus disease 20019 (COVID19) pandemic which first emerged in December 2019 in Wuhan city, China. Currently, a vaccine is urgently needed to control the COVID-19 pandemic. Several vaccine candidates are under development and some are in the final stage of clinical trials. The COVID-19 vaccination aims to reduce morbidity and mortality rates, achieve herd immunity to prevent and protect the society, strengthen the health system, maintain productivity and minimize social and economic impacts. Before approval, vaccines have to undergo several clinical trials to ensure its safety profile, efficacy, duration of immune system resistance, and adverse effect. Various strategies have been used in the development of vaccines including viral vector vaccines, nucleic acid vaccines, inactivated virus, live attenuated virus, subunit protein¸and virus-like particle vaccine. Each strategy has its own advantages and disadvantages.
Exposure to cigarette smoke has been known to be a major risk factor for lung cancer. Although smoking has long been considered the main cause of lung cancer, about 5 to 25% of lung cancer cases occur in non-smokers. Radon is said to be the second most important cause of lung cancer after smoking. Radon-222 is a chemical element in the form of a highly radioactive gas that comes from the decay of the parent radioactive element, uranium, which is found in the earth's crust. Inhaled radon gas can adhere to the mucosal lining of the airways and damage the airway epithelium. The process of ionizing radiation by alpha particles due to the decay of radioactive substances can cause mutations and chromosomal aberrations, severance of DNA double chains, and formation of reactive oxygen species. (ROS) that cause cell cycle changes, up-and down-regulation of cytokines, and increased production of proteins associated with cell cycle regulation and carcinogenesis. Research on radon and lung cancer has not been widely conducted in Indonesia. This literature review aims to describe radon and its effects on lung health.
Background. Bronchiectasis is a chronic inflammatory airway disease characterized by chronic bronchial dilatation. The cause of bronchiectasis is still ideopathic but most of the bronchiectasis are caused by tuberculosis infection and will interfere with the patient's quality of life. In addition, bronchiectasis can be caused by aspiration of foreign bodies. Case presentation. A 42-year-old male patient was treated at Dr, M Djamil Padang Hospital with complaints of coughing up blood, in addition the patient complained of coughing up yellowish phlegm, shortness of breath and fever. The patient had a history of foreign body aspiration 6 months ago. The patient had a chest X-ray and a chest CT scan and a picture of bronchiectasis and mulltiple bullae was found. The patient also had pulmonary tuberculosis infection where the X-pert gene examination in the patient found that MTB was not detected. Conclusion. The patient had multiple bullae, which were complications of emphysema, and the patient had or had compensatory emphysema, where the abnormality was hyperinflation of certain parts of the lung due to atelectasis. The condition of bronchiectasis and multiple bullae makes the patient susceptible to infection, which in this case was found to have pulmonary tuberculosis infection. Management of bronchiectasis includes identification of acute exacerbations and the use of antibiotics, controlling microbial growth, treatment of the underlying condition, and reducing the excessive inflammatory response.
Background: Tuberculosis (TB) and lung cancer cause significant morbidity and mortality worldwide and pose a global health threat. Each year these two diseases account for more than 1.6 million deaths worldwide. The incidence of both diseases is still high in many developing countries, especially in Asian countries. TB and lung cancer are often confused and misdiagnosed, especially in countries with diagnostic challenges of low TB incidence and risk of missed diagnosis.Case Presentation: The following is a case report of a 53-year-old male patient diagnosed with pulmonary TB accompanied by right lung cancer, and the same respiratory complaints can be had by lung cancer and TB. However, the presence of facial edema (part of the superior vena cava syndrome) causes clinicians to focus more on lung cancer so that the diagnosis of TB is often overlooked.Conclusion: Tuberculosis should be a significant concern, especially in patients with malignancies such as lung cancer and located in TB endemic areas. Delay in diagnosis and or miss diagnosis will affect the patient's outcome.
Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality. This study aimed to determine the factors that influenced the outcomes of COVID-19 patients treated at RSUP. Dr. M. Djamil Padang.Methods: This was an observational analytic study conducted with a retrospective cohort design on COVID-19 patients at RSUP Dr. M. Djamil Padang. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients were analyzed using Chi- Square/Fisher Exact Test.Results: Majority of the patients were female (56.4%) and aged above 50 years (64.3%). Hypertension was the most common comorbidity (41.1%). Diabetes mellitus affected the final outcome of treatment. The number of comorbidities the patients had was associated with a worse outcome for COVID-19.Conclusion: Most of COVID-19 patients at RSUP Dr. M. Djamil Padang were male and more than 50 years old. There was a correlation between age, gender, and comorbidities in COVID-19 patients with the outcomes.
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