Effect of Radon and Lung Cancer Risk: A Narrative Literature Review

Abstract

Exposure to cigarette smoke has been known to be a major risk factor for lung cancer. Although smoking has long been considered the main cause of lung cancer, about 5 to 25% of lung cancer cases occur in non-smokers. Radon is said to be the second most important cause of lung cancer after smoking. Radon-222 is a chemical element in the form of a highly radioactive gas that comes from the decay of the parent radioactive element, uranium, which is found in the earth's crust. Inhaled radon gas can adhere to the mucosal lining of the airways and damage the airway epithelium. The process of ionizing radiation by alpha particles due to the decay of radioactive substances can cause mutations and chromosomal aberrations, severance of DNA double chains, and formation of reactive oxygen species. (ROS) that cause cell cycle changes, up-and down-regulation of cytokines, and increased production of proteins associated with cell cycle regulation and carcinogenesis. Research on radon and lung cancer has not been widely conducted in Indonesia. This literature review aims to describe radon and its effects on lung health.

Radon Exposure Assessment in Occupational and Environmental Settings: An Overview of Instruments and Methods

“…The alpha particles emitted during the decay of radon and its progeny can damage lung tissue and DNA, leading to the development of cancerous cells [7]. This risk is further compounded by the fact that radoninduced lung cancer does not exhibit specific symptoms, making it difficult to detect until it has reached an advanced stage [8]. As such, mitigation strategies, such as improving ventilation and conducting regular radon testing, are essential for reducing the risk of exposure and protecting public health.…”