Production and evaluation of modified taro (Colocasia esculentaSchottABSTRAK: Pembuatan dan evaluasi pati talas (Colocasia escuenta Schott) termodifikasi dengan bakteri asam laktat (Lactobacillus sp) telah dilakukan. Tujuan penelitian ini adalah untuk melihat pengaruh modifikasi pati talas dengan bakteri asam laktat terhadap rendemen pati talas dan sifat fisikokimia pati. Evaluasi yang dilakukan meliputi organoleptik, kadar air, pH, sudut angkat, daya pengembangan, temperatur gelatinasi, kadar amilosa, dan pemeriksaan bentuk permukaan granula pati menggunakan SEM (Scanning Electron Microscope). Hasil penelitian menunjukkan rendemen pati talas termodifikasi lebih tinggi (19,24%) daripada pati alami (11,79%). Pemeriksaan organoleptik pati talas termodifikasi menunjukkan hasil yang lebih baik dibandingkan pati talas alami, dimana bau khas talas agak sedikit berkurang dan warnanya lebih putih. Selain itu daya pengembangan dan kadar amilosa pati talas termodifikasi mengalami peningkatan. Hasil lainnya menunjukkan bahwa pada pati talas termodifikasi terdapat perlubangan pada permukaan granulanya.
Fenofibric acid is an active form of fenofibrate which has an antihyperlipidemic effect. Fenofibric acid belongs to BCS class II, which has low solubility and high permeability. The aim of this study was to form multicomponent crystal of fenofibric acid and saccharin that can increase the solubility and dissolution rate, as well as impact on its effectiveness. The ratio of the mixture of fenofibric acid and saccharin was determined using two phase diagram. Characterizations were carried out by Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and the evaluations carried out are solubility, dissolution rate and antihyperlipidemic effectiveness. Based on the two phase diagram a mixture of fenofibric acid and saccharin produce eutectic point at 1:1 mole ratio. Multicomponent crystal showed a decrease in melting point with DSC analysis, no new crystalline phase was formed in X-ray diffraction analysis and did not show any chemical interactions in FTIR analysis. Multicomponent crystal showed an increase in the solubility and dissolution rate. The results of the effectiveness of antihyperlipidemic showed that multicomponent crystal was more effective than fenofibric acid.
ABSTRAKPenelitian tentang formulasi losion antioksidan dari ekstrak buah stroberi (Fragaria ananassa) dengan konsentrasi 0,5; 1; dan 2% telah dilakukan. Aktivitas antioksidan losion ditentukan dengan menghitung nilai IC 50 . Aktivitas antioksidan losion pada konsentrasi 0,5; 1; dan 2% dinilai sebagai antioksidan yang sangat kuat, dengan nilai IC 50 berturut-turut 0,47 ppm; 0,82 ppm; dan 1,53 ppm. Evaluasi formula losion antioksidan meliputi organoleptis, homogenitas, stabilitas, dan pH. Hasil penelitian menunjukkan bahwa sediaan losion tidak berubah dan stabil selama 8 minggu penyimpanan.Kata kunci: antioksidan, losion, stroberi.
ABSTRACT
The research about antioxidant lotion formulation that contain strawberry (Fragaria
Fenofibric Acid (FA) is classified under Biopharmaceutical Classification System (BCS) class II due to its poorly soluble in water and high permeability. The present study aimed to prepare the eutectic mixture of FA with nicotinic acid (NA) and characterize its solid state properties and in vitro dissolution rate, along with its in vivo antihyperlipidemic activity. Solvent drop grinding was the method chosen to prepare the eutectic mixture of FA and NA. Solid-state properties were evaluated using thermal analysis Differential Scanning Calorimetry (DSC), crystallographic analysis Powder X-Ray Diffraction (PXRD), FT-IR spectroscopic analysis, and Scanning Electron Microscopy (SEM). To examine in vivo antihyperlipidemic activity, 16 male Swiss Webster rats were injected with 1% hyperlipidemia-inducing solution, followed by the oral administration of 9.45 mg/kg FA and NA (equivalent to 9.45 mg/kg FA), after which the decrease in cholesterol levels was measured. Two-way ANOVA was used to evaluate the data, followed by Duncan’s multiple range test (95% confidence interval). The results proved that FA formed the eutectic mixture with NA at a molar ratio of 6:4. The eutectic mixture of FA-NA had a better solubility and in vitro dissolution rate compared to intact FA, which also led to notably improved antihyperlipidemic activity.
Kinetika pelepasan zat aktif dari matriks antara kedua formula mengikuti persamaan Higuchi. Hasil penelitian terdahulu menunjukkan bahwa pati pisang kepok mengandung kadar amilopektin
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