The DArk Matter Particle Explorer (DAMPE) is a space experiment designed to search for dark matter indirectly by measuring the spectra of photons, electrons, and positrons up to 10 TeV. The BGO electromagnetic calorimeter (ECAL) is its main sub-detector for energy measurement. In this paper, the instrumentation and development of the BGO ECAL is briefly described. The calibration on the ground, including the pedestal, minimum ionizing particle (MIP) peak, dynode ratio, and attenuation length with the cosmic rays and beam particles is discussed in detail. Also, the energy reconstruction results of the electrons from the beam test are presented.

Hard X-ray Imager (HXI) is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory (ASO-S) mission, which is proposed for the 25th solar maximum by the Chinese solar community. HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV. The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s. An engineering prototype has been developed and tested to verify the feasibility of design. In this paper, we present background, instrument design and the development and test status of the prototype.

Targeting fibroblast-like synoviocyte (FLS) migration and invasion-mediated bone erosion is a promising clinical strategy for the treatment of rheumatoid arthritis (RA). Drug sensitivity testing is fundamental to this scheme. We designed a microfluidic chip-based, cell co-cultured platform to mimic RA FLS-mediated bone erosion and perform drug-sensitive assay. Human synovium SW982 cells were cultured in the central channel and migrated to flow through matrigel-coated side channels towards cell culture chamber where RANKL-stimulated osteoclastic RAW264.7 and osteogenic medium (OS)-stimulated bone marrow mesenchymal stem cells (BMSC) were cultured in the microfluidic chip device, mimicking FLS migration and invasion-mediated bone erosion in RA. These SW982 cells showed different migration potentials to osteoclasts and BMSC. The migration of SW982 cells with high expression of cadherin-11 was more potent when SW982 cells were connected with the co-culture of RAW264.7 and BMSC. Simultaneously, in the co-cultured chamber, tartrate-resistant acid phosphatase (TRAP) activity of RANKL-stimulated RAW264.7 cells was enhanced, but alkaline phosphatase (ALP) activity was decreased in comparison with mono-cultured chamber. Furthermore, it was confirmed that celastrol, a positive drug for the treatment of RA, inhibited SW982 cell migration as well as TRAP activity in the cell-cultured microfluidic chips. Thus, the migration and invasion to bone-related cells was reconstituted on the microfluidic model. It may provide an effective anti-RA drug screen model for targeting FLS migration-mediated bone erosion.

The ground and excited state intramolecular proton transfer mechanisms of 3-HTCA and 3-HTC-DiCN have been investigated systematically.

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Aiming at the coordination control problem of the static synchronous compensator (STATCOM) and generator excitation in a multi-machine system, an improved multi-objective holographic feedback (IMOHF) control method is proposed to ensure good dynamic and static state performance of each state in the system. First, the essence of IMOHF is deduced by the Hartman-Grobman theorem. The nonlinear differential algebraic equation (NDAE) system is used to arrange the poles in the vicinity of the equilibrium point by nonlinear feedback; the feedback coefficients are adjusted to constrain the objective variables, so that the variables converge rapidly in their respective references. Then this design concept is applied to the decentralized coordination control strategy of STATCOM and generator excitation. Two kinds of multi-objective holographic feedback nonlinear control laws with active power, synchronous speed, generator terminal voltage, and STATCOM terminal voltage as control objectives are obtained. Simulation result of the three-machine nine-bus system shows that these two kinds of control laws can effectively restrain the power system oscillation and improve the transient stability of the system, and consequently the system voltage will not generate any static shift under different disturbances.

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