Objective To determine population-based incidence estimates of BCC and cSCC. Patients and Methods We reviewed the medical records of a population-based cohort diagnosed with nonmelanoma skin cancer between January 2, 2000 and December 31, 2010. Sex- and age-adjusted incidence rates were calculated and compared to estimates from previous periods. Results The age-adjusted BCC incidence per 100,000 persons was 360.0 (95% CI, 342.5–377.4) for men and 292.9 (95% CI, 278.6–307.1) for women. The age-adjusted cSCC incidence per 100,000 persons was 207.5 (95% CI, 193.9–221.1) for men and 128.8 (95% CI, 119.4–138.2) for women. From years 1976–1984 to 2000–2010, the age- and sex-adjusted BCC incidence per 100,000 persons increased from 222.0 (95% CI, 204.5–239.5) to 321.2 (95% CI, 310.3–332.2), and from 61.8 (95% CI, 52.3–71.4) to 162.5 (95% CI, 154.6–170.3) for cSCC. Over time, the anatomical distribution of BCC shifted from the head and neck to the torso, and cSCC shifted from the head and neck to the extremities. Conclusions The incidences of BCC and cSCC are increasing, with a disproportionate increase in cSCC relative to BCC. There is also a disproportionate increase in women of both tumors, and shifting of anatomical distributions.

A previous history of drug reactions and clindamycin causation were more common in the present cohort than in prior reports. A small subset of patients experienced new-onset non-AGEP skin eruptions within a few months of the resolution of AGEP.

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