Diagnosing calciphylaxis: A series of cases with both imaging and tissue biopsy

Alniemi, Dema T.; Kanner, Christopher D.; Stowman, Anne M.; Knapp, Maxwell; McGevna, Laura; Seward, David J.; Bui, Melanie R.

doi:10.1016/j.jaad.2020.05.111

Cited by 6 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systemic arteriolar medial calcification with intimal fibrosis and thrombosis are typical histopathology features 9 . Additionally, the existence of risk factors and non‐invasive imaging tools (X‐rays, computed tomography (CT) and bone scintigraphy) have also been helpful in diagnosis 10–13 . Included patients had to be diagnosed with calciphylaxis firstly and ≥18 years.…”

Section: Methodsmentioning

confidence: 99%

Clinical features and outcomes of calciphylaxis in Chinese patients with chronic kidney disease

et al. 2023

View full text Add to dashboard Cite

Aim: Calciphylaxis is a rare disease, predominantly in chronic kidney disease (CKD), characterized by high morbidity and mortality. Data from the Chinese population have been an invaluable resource for a better understanding of natural history, optimal treatments and outcomes of calciphylaxis.Methods: A retrospective study was conducted in 51 Chinese patients diagnosed with calciphylaxis at Zhong Da Hospital affiliated to Southeast University from December 2015 to September 2020.Results: Between 2015 and 2020, 51 cases of calciphylaxis were registered in The China Calciphylaxis Registry (http://www.calciphylaxis.com.cn), which was developed by Zhong Da Hospital. The mean age of the cohort was 52.02 ± 14.09 years, and 37.3% were female. Forty-three patients (84.3%) were on haemodialysis, with a median dialysis vintage of 88 months. Eighteen patients (35.3%) had a resolution of calciphylaxis and 20 patients (39.2%) died. Patients in later stages had higher overall mortality than those in earlier stages. Delay from skin lesions onset to diagnosis and calciphylaxis-related infections were risk factors in both early and overall mortality.Additionally, dialysis vintage and infections were significant risk factors in calciphylaxis-specific mortality. Among therapeutic strategies, only the use of sodium thiosulfate (STS) ≥3 courses (14 injections) was significantly associated with decreased hazard of death in both early and overall mortality. Conclusion:For Chinese patients with calciphylaxis, delay from skin lesions onset to diagnosis and infections secondary to wounds are risk factors for the prognosis of patients with calciphylaxis. Additionally, patients in earlier stages have better survival and early continuous use of STS is highly suggested.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical features and outcomes of calciphylaxis in Chinese patients with chronic kidney disease

et al. 2023

View full text Add to dashboard Cite

show abstract

“…41 The role of imaging in the diagnosis of calciphylaxis has garnered attention, particularly when biopsy studies are inconclusive or invasive procedures are not possible. [42][43][44] Plain radiographic findings that have been associated with calciphylaxis include presence of small-vessel calcification, and a netlike pattern of calcification. Of these, one study found that while the presence of vascular calcification had the highest sensitivity for calciphylaxis (89.2, CI = 73.0 -100), a netlike pattern of calcification exhibited the greatest specificity (89.9, CI = 82.7 -97).…”

Section: Diagnosis Of Calciphylaxismentioning

confidence: 99%

Calciphylaxis and Kidney Disease: A Review

Marin

Aghagoli²,

Hu³

et al. 2023

American Journal of Kidney Diseases

View full text Add to dashboard Cite

“… 7 , 8 Often, biopsies are nondiagnostic due to inadequate sampling or nonspecific histologic features. 9 Although incisional biopsies are recommended, these may not be appropriate when considering patient comfort, infection risk, and wound healing. Plain films, computed tomography, and ultrasound can be useful diagnostic modalities, along with contrast-based vascular imaging to detect calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Plain films, computed tomography, and ultrasound can be useful diagnostic modalities, along with contrast-based vascular imaging to detect calcification. 9 , 10 , 11 Given our patient’s acute renal injury, contrast-based imaging was not pursued.…”

Section: Discussionmentioning

confidence: 99%