When navigating, women typically focus on landmarks within the environment, whereas men tend to focus on the Euclidean properties of the environment. However, it is unclear whether these observed differences in navigational skill result from disparate strategies or disparate ability. To remove this confound, the present study required participants to follow either landmark-or Euclidean-based instructions during a navigation task (either in the real-world or on paper). Men performed best when using Euclidean information, whereas women performed best when using landmark information, suggesting a dimorphic capacity to use these 2 types of spatial information. Further, a significant correlation was observed between the mental rotation task and the ability to use Euclidean information, but not the ability to use landmark information.
The current study assessed the construct validity of the Drive for Muscularity Scale (DMS; D. R.McCreary & D. K. Sasse, 2000) using both lower and higher order exploratory factor analysis (EFA). In a sample of male and female high school and college students, lower order EFAs showed that a 2-factor structure emerged for men (muscularity attitudes and behaviors), but not for women, although 11 of the 15 items overlapped across gender. A higher order EFA using the male 2-factor structure revealed the presence of a single, higher order DMS factor in both genders. It is argued that the overall DMS score can be used in samples of both men and women. However, the attitude and behavioral DMS subscales can be used validly only in men.
Hippocampal lesions impair spatial learning in the watermaze. Drugs that antagonize N-methyl-D-aspartate (NMDA)-receptor activity, which is required for long-term potentiation (LTP) at various hippocampal synapses, block LTP and impair watermaze learning. This has led to the hypothesis that NMDA receptors, through their involvement in LTP, may be necessary for spatial and other forms of learning. We examined this hypothesis using NPC17742 (2R,4R,5S-2-amino-4,5-(1,2-cyclo hexyl)-7-phosphonoheptano acid), a potent and specific antagonist of NMDA receptors. Here we report that NPC17742 completely blocked dentate gyrus LTP but did not prevent normal spatial learning in rats that had been made familiar with the general task requirements by non-spatial pretraining. Although these results do not rule out a contribution of NMDA-mediated dentate LTP to spatial learning, they indicate that this form of LTP is not required for normal spatial learning in the watermaze.
Prior qualitative research has suggested that people assume muscular men are more masculine. This assumption was tested quantitatively in 2 studies. In Study 1, men and women completed measures of gender-role traits and behaviors, whereas in Study 2, men completed measures of gender-role conflict and traditional attitudes about men. Study 1 revealed a correlation between self-rated male-typed traits and behaviors, with a need to be more muscular for both men and women. In Study 2, men with more traditional attitudes about men also wanted to be more muscular; men who wanted to be more muscular were experiencing conflict with regard to society's expectations that they be successful, powerful, and competitive, and they reported that finding a balance between work and leisure is difficult.
A detailed behavioral analysis of water-maze acquisition showed that the N-methyl-D-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performances and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze.
Aging is associated with deterioration of skilled manual movement. Specifically, aging corresponds with increased reaction time, greater movement duration, segmentation of movement, increased movement variability, and reduced ability to adapt to external forces and inhibit previously learned sequences. Moreover, it is thought that decreased lateralization of neural function in older adults may point to increased neural recruitment as a compensatory response to deterioration of key frontal and intra-hemispheric networks, particularly of callosal structures. However, factors that mediate age-related motor decline are not well understood. Here we show that music training in childhood is associated with reduced age-related decline of bimanual and unimanual motor skills in a MIDI keyboard motor learning task. Compared to older adults without music training, older adults with more than a year of music training demonstrated proficient bimanual and unimanual movement, evidenced by enhanced speed and decreased movement errors. Further, this group demonstrated significantly better implicit learning in the weather prediction task, a non-motor task. The performance of older adults with music training in those tasks was comparable to young adults. Older adults, however, displayed greater verbal ability compared to young adults irrespective of a past history of music training. Our results indicate that music training early in life may reduce age-associated decline of neural motor and cognitive networks.
A detailed behavioral analysis of water-maze acquisition showed that the JV-methyl-D-aspartate (NMDA) antagonist NPC17742 and the muscarinic antagonist scopolamine caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze in male rats. Behavioral disturbances included thigmotaxic swimming, swimming over and deflecting off the platform, abnormal swim behavior, and hyperactivity. Rats familiar with the behavioral strategies involved in the task performed normally under NPC17742 or scopolamine. The results indicated that drug-induced sensorimotor disturbances contributed to poor acquisition scores in naive rats. NMDA or muscarinic activity may contribute to but do not appear to be essential for spatial learning in the water maze.The previous article reported results of a detailed behavioral analysis of water maze acquisition under D,L-2-amino-5phosphonovalerate (APV), an JV-methyl-D-aspartate (NMDA) receptor antagonist, and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA excitatory amino acid receptor antagonist (Cain, Saucier, Hall, Hargreaves, & Boon, 1996). The findings confirmed and extended previous observations of sensorimotor disturbances and documented several novel disturbances that occurred consistently in naive rats tested under CNQX or APV. A correlational analysis showed that there was a consistent association between a wide variety of sensorimotor disturbances and poor acquisition scores in both the hidden and visible platform versions of the maze and in nonmaze tasks such as walking along a narrow beam. These findings arc consistent with, but do not prove, the idea that the sensorimotor disturbances caused some or all of the inferred learning deficit, as reflected by conventional measures of water-maze acquisition.A striking finding of the study was that prior familiarity with the requirements of the task by nonspatial pretraining (Davis, Butcher, & Morris, 1992;Morris, 1989) resulted in rapid learning of the task when the rats were later trained under
Temporal lobe epilepsy, the most common type of epilepsy in adult humans, is characterized clinically by the progressive development of spontaneous recurrent seizures of temporal lobe origin and pathologically by hippocampal neuronal loss and mossy fiber sprouting. In this study, we sought to test the prominent hypothesis that neuronal loss and mossy fiber sprouting play a critical role in the genesis and progression of temporal lobe epilepsy. Rats receiving a single kainic acid injection experienced a single sustained episode of epileptic status with massive neuronal loss and mossy fiber sprouting, whereas rats receiving triple kainic acid injections experienced two priming episodes and one sustained episode of epileptic status with no detectable neuronal loss and mossy fiber sprouting. Early in the process of chronic seizure development, primed rats that failed to show detectable neuronal loss and mossy fiber sprouting exhibited a starting date and a frequency of spontaneous recurrent seizures similar to those of nonprimed rats that showed massive neuronal loss and mossy fiber sprouting. However, nonprimed rats displayed significantly prolonged episodes of spontaneous recurrent seizures over the whole process of chronic seizure development and more frequent severe seizures later in the process. Similar results were observed in both Fischer-344 and Wistar rats as well as in the rat pilocarpine preparation of temporal lobe epilepsy. These results fail to reveal a relation between neuronal loss-mossy fiber sprouting and the genesis of temporal lobe epilepsy but suggest that neuronal loss, mossy fiber sprouting, or both contribute to the intensification of chronic seizures.
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