ObjectiveTo evaluate the association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC).Materials and MethodsThe patients were evaluated by ultrasonography-guided fine needle aspiration cytology. Typical cytopathological aspects and/or classical histopathological findings were taken into consideration in the diagnosis of HT, and only histopathological results were considered in the diagnosis of PTC.ResultsAmong 1,049 patients with multi- or uninodular goiter (903 women and 146 men), 173 (16.5%) had cytopathological features of thyroiditis. Thirty-three (67.4%) out of the 49 operated patients had PTC, 9 (27.3%) of them with histopathological features of HT. Five (31.3%) out of the 16 patients with non-malignant disease also had HT. In the groups with HT, PTC, and PCT+HT, the female prevalence rate was 100%, 91.6%, and 77.8%, respectively. Mean age was 41.5, 43.3, and 48.5 years, respectively. No association was observed between the two diseases in the present study where HT occurred in 31.1% of the benign cases and in 27.3% of malignant cases (p = 0.8).ConclusionIn spite of the absence of association between HT and PCT, the possibility of malignancy in HT should always be considered because of the coexistence of the two diseases already reported in the literature.

OBJETIVO: Verificar o efeito da injeção percutânea de etanol guiada por ultra-sonografia no tratamento dos nódulos tireoidianos císticos. MATERIAIS E MÉTODOS: Comparou-se o volume de 34 nódulos benignos císticos, em 30 pacientes (26 do sexo feminino e quatro do sexo masculino), antes e uma média de 3,9 meses depois da alcoolização. O volume inicial dos nódulos foi avaliado por dois observadores, que realizaram a ultra-sonografia em momentos diferentes, sem qualquer informação prévia a respeito do tamanho dos nódulos, cuja finalidade foi conhecer a variação interobservador das medidas ecográficas. RESULTADOS: A média de volume dos nódulos antes do tratamento foi de 12,3 ± 18,0 ml. A média de redução de volume foi de 74,0 ± 26,1% (p = 0,0001), e 20,6% (7/34) deles desapareceram. Não houve correlação entre o volume inicial e o percentual de redução dos nódulos. A média de variação das medidas interobservadores foi de 0,5 ml para um alfa de 5%. Dor moderada, no momento da aplicação, foi a complicação mais freqüente. CONCLUSÃO: A injeção percutânea de etanol é uma opção segura e eficaz no tratamento dos nódulos tireoidianos císticos.

To verify the effectiveness of percutaneous ethanol injection (PEI) in the treatment of thyroid nodules (TN), we analyzed 86 TN from 77 patients before and after one or two sessions of PEI. The medians of the initial and final volumes were: 3.5 mL (range 0.3-82.7) and 1.8 mL (range 0-29.4). Seven percent of the nodules disappeared and the mean nodule size reduction was 52.6% (p< 0.0001). After ethanol injection, the median volume reduction was: 37.3% (range -39.0-82.6) for solid; 53.5% (14.6-88.0) for mostly solid; 58.0% (21.0-64.5) for mixed; 71.0% (18.8-100.0) for mostly cystic and 90.0% (45.9-100.0) for cystic lesions. Furthermore, we compared the variation of the greatest diameter of TN, without any treatment and after PEI, and found this difference statistically significant (p< 0.00001). Pain was the most common complication, although this was mostly described as moderate (27.6%). We conclude that PEI is an efficient and safe treatment option for benign TN.