Among hypogonadal men, those with T2D have higher BMD, poorer bone geometry and relatively suppressed bone turnover. Studies with larger sample size are needed to verify our findings and possible even greater risk for fractures among hypogonadal diabetic men.

Objective: Because the aromatase enzyme catalyzes the conversion of testosterone to estradiol (E 2 ), the activity of this enzyme could be important in the musculoskeletal health of men with low testosterone. The objective of the present study is to determine the influence of aromatase activity on the bone mineral density (BMD) and body composition of patients with hypogonadism. Design: Cross-sectional study. Methods: The baseline data of 90 patients between 40 and 74 years old who participated in a genetic study of response to testosterone therapy in men with low testosterone (i.e., !300 ng/dl) were analyzed. BMD and body composition were measured by dual-energy X-ray absorptiometry. Serum testosterone was measured by automated immunoassay, E 2 was measured by ultrasensitive enzyme immunoassay, and sex hormone-binding globulin was measured by enzyme immunoassay. Results: Men in the highest tertile of E 2 to testosterone ratio (E 2 :T) had the highest spine BMD (P%0.037), highest truncal fat (PZ0.046), and lowest truncal lean body mass (PZ0.045). A similar pattern was observed in the upper extremities; that is, fat mass significantly increased (PZ0.047), whereas lean mass significantly decreased (PZ0.034) with increasing E 2 :T tertiles. Conclusion: The present findings suggest that in men with hypogonadism, aromatase activity could be an important determinant of musculoskeletal health. Men with high aromatase activity are able to maintain a higher BMD despite low circulating testosterone, but they have lower lean and higher truncal fat mass as compared to those with lower aromatase activity.

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Environmental journalists have been at the forefront of news industry changes. Over the past 30 years, they have had to deal with a range of challenges, including increased complexity, greater reliance on data, exposure to online negativity, and cooption into polarised political debates. At the same time, they have been among the most vulnerable to newsroom cutbacks. This exploratory study examines the extent to which environmental journalists can be considered emblematic of challenges facing beat journalism in general. Drawing on rare, onthe-record interviews with environmental reporters in the US, UK, and Ireland, the study finds that, based on environmental journalists' experiences, specialised environmental beats are becoming the preserve of larger media organisations with dedicated audiences, while at smaller news outlets, specialist reporters have taken on two or more beats, thereby diluting coverage of specific areas overall. Environmental journalists have also had to reconsider traditional roles, such as the conduit function, and long-standing norms, such as objectivity and impartiality. These trends may come to be replicated across other beats as journalists begin to report from a social justice standpoint, or rely more on science and data, as has happened during Covid-19 coverage.

Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes include: areal bone mineral density (aBMD) and body composition by dual-energy X-ray absorptiometry; volumetric BMD (vBMD) and soft tissue composition of the tibia by peripheral quantitative computed tomography. Fracture risk assessment tool (FRAX) scores were evaluated. Testosterone, estradiol, luteinizing hormone, follicle stimulating hormone, sex hormone-binding globulin, C-telopeptide, osteocalcin, and sclerostin were measured. We divided the population into subgroups of BMI: group 1: BMI < 30; group 2: BMI ≥30 to <35 and group 3: BMI ≥ 35 kg/m. One-hundred five men were enrolled. Spine and hip aBMD, and total and trabecular vBMD at the 4% tibia significantly increased with increasing BMI. Cortical thickness (330.7 ± 53.2, 343.3 ± 35.4, and 358.7 ± 38.2 mm, p = 0.04; groups 1, 2 and 3, respectively) and cortical area (5.3 ± 0.7, 5.5 ± 0.6, and 5.7 ± 0.6 mm, p = 0.01; groups 1, 2 and 3, respectively) at 38% tibia increased with increasing BMI. While absolute lean mass increased with increasing BMI, % lean mass and muscle density (70.2 ± 5.0, 71.3 ± 6.4, and 67.1 ± 5.1 mg/cm; groups 1, 2 and 3, respectively) were lowest in group 3. Although severely obese hypogondal men have better BMD and bone quality, they have reduced muscle density, the significance of which remains to be determined.

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