No abstract

No abstract

The short-term toxicity of Ficus thonningii Blume (FT) was studied in Wistar rats following daily oral administration of the leaf extract (250-500 mg kg )1 ) for 15 days. Acute toxicity, body weight changes, organ weight, food intake, clinical signs, haematology, gross and tissue histology were monitored. The body weights of treated rats increased progressively, but the changes were not significantly different from control. The relative weights of the essential organs of treated rats were unaffected in both male and female rats. Of the sixteen haematological parameters studied, only the total leukocyte counts and plateletcrit values in male rats fed 500 mg kg )1 of FT were significantly greater than similar parameters in controls. Histological findings indicated possible testicular, lung and hepatic toxicities. The LD 50 of FT was estimated to be >3000 mg kg )1 . The results suggest that short-term oral application of F. thonningii may not exert severe toxic effects in rats at doses lower than 500 mg kg )1 .

An evaluation of the effects of rinbacin on the liver and blood of albino rats was carried out. Low (26.25 g/l) and high (52.50 g/l) dose levels of rinbacin were administered in the drinking water of albino rats for 13 weeks. Food and fluid intake were measured daily, and animal body weight taken weekly. Biochemical analysis of the liver function was carried out as well as some haematological parameters and histology of the liver. Results showed a significant (p ≤ 0.05) increase in all the liver function parameters tested at both dose levels. There was also an increase in packed cell volume (PCV) in the high dose group. Histological examination indicates that rinbacin at both dose sizes induced severe pathologic changes in the forms of degeneration of hepatocytes, necrosis, oedema, cellular infiltration, nuclear fragmentation and chromatinolysis. Administration of rinbacin, though could raise the PCV, may lead to hepatic damage, which might result in increased bilirubin and liver enzymes in rats. Rinbacin is toxic to the rat liver.

Introduction:We evaluated the sub-chronic toxicity of the aqueous herbal extract prepared from Cassytha filiformis and administered daily for 28 days at dose levels (250, 500, and 1000 mg/kg bw) in male wistar albino rats. The LD 50 of the aqueous extract was determined.Methods: The effects on body weights, organ weights, and certain haematological and plasma biochemical parameters were measured as indices of organ toxicity.Results: The aqueous extract did not affect plasma glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT); however, a significant reduction in alkaline phosphatase (ALP) level occurred in all the treated groups. It also did not affect the electrolytes (Naϩ, ClϪ and Kϩ), total and direct bilirubin, creatinine, and glucose level. The aqueous extract elicited hypercholesterolaemic effects, but it did not affect the Hb, WBC, RBC, PVC, platelets, MCH, MCHC, MCV levels and differential counts (lympocytes, neutrophils, monocytes, eosinophils and basophils). It also reduced the body weight gain and absolute weight of the kidneys. The relative weights of the heart and lungs in some animal groups were equally reduced. The acute toxicological evaluation of the plant extract revealed an oral LD 50 value greater than 500 mg/kg bw.Conclusion: This study suggests that aqueous extract of C. filiformis administered at normal therapeutic doses is not likely to produce severe toxic effects on some organs or haematological and biochemical indices in rats.

No abstract

No abstract

No abstract