Zinc Protection of Mercury-Induced Hepatic Toxicity in Mice.

Afonne, Onyenmechi Johnson; Orisakwe, Orish Ebere; Ndubuka, Gideon I.; Akumka, David D.; Ilondu, Ndidi

doi:10.1248/bpb.23.305

Cited by 17 publications

(10 citation statements)

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“…In addition, level of serum T 4 in Pb+Zn group was the lowest among the four groups. In Zn group, serum T 3 was significantly lower than that in controls and whereas there were no significant differences in the serum T 4 and cortisol compared with controls.…”

Section: Resultsmentioning

confidence: 60%

“…The levels of serum T 3 , T 4 and cortisol in four groups of rats were shown in Table 4. In Pb group or Pb+Zn group, serum T 3 and T 4 were significantly lower, and on the contrary, serum cortisol were significantly higher than those in controls.…”

Section: Resultsmentioning

confidence: 99%

“…Since the recognition of zinc (Zn) as an essential nutrient, many researchers have studied its role in the prevention and treatment of toxic metals such as lead (Pb), cadmium and mercury, as well as organic solvents such as ethanol and carbon tetrachloride [1][2][3][4][5][6] . In particular, these studies have mainly focused on the protective effects of Zn on Pb toxicities.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Zinc Coadministration on Lead Toxicities in Rats

et al. 2007

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In order to investigate the effects of Zn on Pb toxicities. Proportion of abnormal sperm, percentage of micronucleated polychromatic erythrocyte (MPCE), serum thyroid hormones (T 3 , T 4 ) and cortisol were measured. Rats received intraperitoneal injection of 25 mg/kg Pb acetate, 4 mg/kg Zn acetate, both Pb acetate and Zn acetate, or normal saline as controls, once every two days, 7 times in total. No significant differences in whole blood Pb were detected between groups received Pb alone or both Pb and Zn. On the contrary, the concentration of whole blood Zn in the group given Zn alone was significantly higher than that in the group that received both Pb and Zn. In the groups given Pb alone or both Pb and Zn, proportion of abnormal sperm, frequency of MPCE and serum cortisol were significantly higher than those in controls, whereas serum T 3 and T 4 were significantly lower than in controls. In the group given both Pb and Zn, T 4 was decreased most obviously among the four groups. While the proportion of abnormal sperm was less in the group given both Pb and Zn than in the group given Pb alone. These findings suggest that Zn coadministration might alleviate toxic effects of Pb on the male reproductive system, whereas it could enhance the toxicity on thyroid function. Zn did not affect the toxicities of Pb on cytogenetic systems as indicated by MPCE percentage, and on serum cortisol levels under the dose of the present study. Our results suggested the double-edged effects of Zn on Pb toxicities in different organs. Therefore, the effects of Zn on Pb toxicities should be evaluated systematically.

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Section: Resultsmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Zinc Coadministration on Lead Toxicities in Rats

et al. 2007

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“…Decrease in body weights of the rats was observed except in the control, it could be due to the fact that H. sabdariffa is very sour in taste, which may decrease the apatite and resulted in decreased food intake or consumption which ultimately may lead to decrease in the weights observed (Afonne et al, 2002;Orisakwe et al, 2003) or alternatively it may have some effect on glucose or lipid metabolism. In conclusion, sub-chronic administration of calyx extracts of H. sabdariffa has the potential of causing toxic effects on both liver and kidney but more research should be encouraged to ascertain the safety dose level of calyx of H. sabdariffa in humans.…”

Section: Discussionmentioning

confidence: 91%

Hepatorenal toxicity studies of sub-chronic administration of calyx aqueous extracts of hibiscus sabdariffa in albino rats

Abubakar¹,

Lawal²,

Suleiman³

et al. 2010

Bayero J. Pure App. Sci.

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Hibiscus sabdariffa Linn has been reported to have a broad range of therapeutic effects. Subchronic effects of calyces aqueous extracts of H. Sabdariffa were studied in albino rats. Twenty four (24) albino rats were randomly divided into six (6) groups of four rats each. Group A, was fed with growers mesh and distilled water as control. Groups B to F were administered orally with the aqueous extract at 1, 2, 3, 4 and 5g /kg body weight respectively and the treatment period was 28 days. A decreased in weights of the animals were observed at all dose levels. The activities of liver maker enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and direct bilirubin increased significantly (p<0.05) in comparison to the control. However, non significant (p>0.05) increase in concentrations of total protein and albumin were observed in comparison to the control. The renal indices, urea, uric acid and creatinine in the treated groups were significantly increased compared to the control but a significant decrease (p<0.001) in sodium (Na + ) and potassium (K + ) were noted in comparison to the control. Although the results revealed a dose dependant variation in the liver and renal indices, nonetheless these results suggest that high dose of calyx extracts of H.sabdariffa may be toxic to liver and kidney.

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“…Zinc pretreatment had been shown to protect the liver in many mammal models. [20][21][22][23][24] The mechanism of the zinc-mediated liver protection is related to the increase in hepatic metallothionein concentration. Metallothionein is easily inducible by metal ions and can scavenge reactive oxygen species that cause serious cellular injuries.…”

Section: Discussionmentioning

confidence: 99%