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The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.

Aim-To elucidate the diurnal variation in human corneal thickness over a 48 hour period. Method-Changes in central corneal thickness were monitored in eight healthy subjects (four male, four female) aged between 10 and 63 years using an ultrasonic pachymeter. Measurements were made over a 48 hour period-immediately before sleep, immediately upon waking and at 15, 30, 45 minutes, 1, 1.5, 2, 2.5, 3 hours, and at 2 hour intervals thereafter throughout the remainder of each day. Results-The mean corneal thickness for the group (SD) was 546 (14) ptm, with a mean overnight increase of 5.5% (2.90/6) (range 1.9-12.6%) and a maximum diurnal increase of 7.2% (2.8%) (range 2.1-14.3%). Individual differences in the extent of diurnal and overnight variation occurred within the group. For three subjects, the first reading taken on waking was not the highest and corneal thickness continued to increase. Conclusion-These data confirm an increase of corneal thickness during sleep, but also reveal considerable variation during waking hours. Thus, the overnight changes in corneal thickness are not truly representative of diurnal variations in human corneal thickness and, in fact, much greater diurnal variation occurs than the 3.0-4.4% previously reported. (BrJ Ophthalmol 1996;80:1068-1072 Corneal thickness measurements are indicative of the metabolic status of the cornea, as they provide an index of corneal hydration.' Such measurements give valuable information on the physiological status of the cornea and its changes associated with disease,2' trauma,56 and hypoxia.78 The healthy human cornea experiences hypoxia on a daily basis beneath the closed eyelid during sleep.910 The reduction in oxygen levels beneath the closed eyelid is thought to induce anaerobic metabolism, which causes an accumulation of lactate within the stroma which is followed by an osmotic influx of water.7 Other factors could also influence corneal hydration such as the reduced evaporation from the tear film which occurs during the first 2 hours of waking," intraocular pressure which increases rapidly after sleep,'2 and body temperature which changes on a diurnal basis decreasing during night-time sleep and increasing throughout the day.'3 Upon opening the eyelid at waking the corneal thickness is reputed to return rapidly to normal. Thus, corneal thickness changes on a diurnal basis. Such diurnal variations in corneal thickness have been identified in a variety of species, including rabbit,'4 cat,'5 primate,'6 and human.9 17-20It still remains unclear whether overnight changes in human corneal thickness are truly representative of the diurnal variation occurring throughout any 24 hour period or whether the pattern of thickness changes is the same on consecutive days. The aim of this study was to use ultrasonic pachymetry to elucidate the diurnal variation in human corneal thickness in a group of normal healthy human subjects over a 48 hour period. Materials and methods SUBJECTSEight subjects (four male, four female) aged between 10 and 63 years partici...

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