Stratified Media Model for Terahertz Reflectometry of the Skin

Bennett, David; Li, Wenzao; Taylor, Zachary D.; Grundfest, Warren S.; Brown, E. R.

doi:10.1109/jsen.2010.2088387

Cited by 76 publications

(87 citation statements)

References 50 publications

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“…Given the permittivity of the sample and the dehydrated tissue, also called the biological background, the volume fraction (14,15) and stratified media theory can be used to calculate the reflectivity of samples resembling multi-layer structures (16). This approach has been used successfully in vivo on both rat skin (17) and rabbit cornea (18)(19)(20).…”

Section: Tissue Modellingmentioning

confidence: 99%

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Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

221

113

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Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

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Section: Tissue Modellingmentioning

confidence: 99%

“…For all EMAs, the accuracy of the underlying material permittivity is crucial. Researchers have used dehydrated tissue to estimate the biological background (16,22), and Debye theory and finite difference time domain (FDTD) methods have been used to model the THz response of breast (23) and skin (24) tissue.…”

Section: Tissue Modellingmentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

221

113

View full text Add to dashboard Cite

show abstract

“…3 report the approximate change in water concentration as computed from the measured THz reflectivity and a recently reported skin model. 10 In this model the skin is assumed a homogenous medium consisting of a mixture of collagen water with experimentally measured dielectric functions. 10 The volume fraction of water to collagen required to yield the observed reflectivity was then computed.…”

mentioning

confidence: 99%

In vivo terahertz imaging of rat skin burns

et al. 2012

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“…2(a)], so that only the surface of the skin was facing the TPX window. Both tissue samples were in excess of 5 mm thick, to effectively ensure no THz reflection from the backing plate [25].…”

Section: Sample Preparationmentioning

confidence: 99%

High-contrast coherent terahertz imaging of porcine tissue via swept-frequency feedback interferometry

Lim

Taimre

Bertling

et al. 2014

Biomed. Opt. Express

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There is considerable interest in the interrogation of biological tissue at terahertz (THz) frequencies, largely due to the contrast in the optical properties of different biological tissues which occur in this electro-magnetic radiation band. Of particular interest are THz biomedical images, which have the potential to highlight different information than those acquired in other frequency bands, thereby providing an augmented picture of biological structures. In this work, we demonstrate the feasibility of an interferometric biological imaging technique using a THz quantum cascade laser (QCL) operating at 2.59 THz to perform coherent imaging of porcine tissue samples. We show the potential of this new THz biomedical imaging technique for in vivo studies, by virtue of its reflection geometry and useful tissue penetration depth enabled by the large THz powers emitted by the quantum cascade laser used in this work. The observed clustering of interferometric tissue signatures opens a pathway towards automatic techniques for the discrimination of healthy tissue types for the study of normal physiology and possible therapeutic approaches.

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Stratified Media Model for Terahertz Reflectometry of the Skin

Cited by 76 publications

References 50 publications

Recent advances in terahertz technology for biomedical applications

Recent advances in terahertz technology for biomedical applications

In vivo terahertz imaging of rat skin burns

High-contrast coherent terahertz imaging of porcine tissue via swept-frequency feedback interferometry

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