Combretum glutinosum Perr. Ex DC (COMBRETACEAE) is a traditional medicinal plant, widely distributed in Senegal and Africa. The aim of that study was to investigate the analgesic and anti-inflammatory activities of two triterpenes, betulonic acid (DN7) and cabraleone (DN12), isolated from the leaves of Combretum glutinosum. Experiments were performed in acetic acid-induced contortions in mice and carrageenan rat paw oedema. DN7 (3 mg/kg, per os) and DN12 (3 mg/kg, per os) significantly prevent contortions in mice. The number of contortions is respectively 30±10 and 32±7 versus 72.6±6.64 in control group (p<0.05, n=5). DN7 (3 mg/kg, per os) significantly prevented the increased rat paw oedema (31.84±6.76 vs 92.72±6.05%) (p<0.05, n=5). DN12 (10 mg/kg, per os) induced rat paw oedema prevention similar to that of acetylsalicylic acid (10 mg/kg, per os) administered in the same conditions (29.28±5.88 vs 30.96±7.25%; ns, n=5). The analgesic and anti-inflammatory activities of triterpenes isolated from C. glutinosum leaves are similar to those of non-steroidal anti-inflammatory drugs such acetylsalicylic acid, justifying the use of this plant in traditional medicine to manage pain and inflammation.
Structural determination of triterpenoids isolated from leaves combretum glutinosum Perr. Ex DC (Combretaceae)ABSTRACT Combretum glutinosum Perr.Ex DC is a plant of the Senegal traditional pharmacopoeia whose leaves are used in the treatment I of various diseases. Four triterpenoids betulinol 1, betulonal 2, betulonic acid 3 and cabraleone 4 were isolated from the hexane and dichloromethane extracts of the leaves. Isolation and characterization of this compounds were respectively done by chromatography on silica gel and by NMR (1D, 2D) and ESI-MS spectral analysis. This work allowed us to confirm the ethnopharmacological studies carried out on this plant.
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