Most of diseases are due to the "oxidative stress" resulting from an imbalance between formation and neutralization of pro-oxidants. Oxidant stress is initiated by free radicals, which produced aerobic metabolism in the body, can cause oxidative damage of biological macromolecules such as proteins, lipids, and DNA in healthy human cells (Yen and Chen, 1995; Gutteridge and Halliwell, 1993; Halliwell, 1995). These changes contribute to oxidative stress that is among the major causative factors in the induction of many chronic and degenerative diseases including atheorosclerosis, ischemic heart diseases and diabetes mellitus,
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