Detection on Antioxidant and Cytotoxicity Activities of Exopolysaccharides Isolated in Plant-Originated Lactococcus lactis

Nguyen, Dao Ta; Nguyen, Tu Hk

doi:10.13005/bpj/449

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…In recent years, there have been many studies using animal models, which have clearly demonstrated a protective effect of dietary supplements of LAB against colon tumor development [42]. The antioxidant activity of the extracts of the culture of Lactobacillus rhamnosus PN04 and Lactococcus lactis PN05 showed the DPPH (2,2′-diphenyl-1-picrylhydrazyl radical) scavenging assay [43]. The effect of two LAB strains to cancer cell lines is fairly similar.…”

Section: Representative Probioticsmentioning

confidence: 97%

Medicinal Herbs and Probiotics: Antioxidant Activities for Damaged DNA Protection and Cytotoxicity toward Cancer Treatment

Nguyen

2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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Oxidative stress is an imbalance between oxidation and antioxidant responses caused by the accumulation of free radicals in the body. Cells produce free radicals that cause oxidative damage such as aging, atherosclerosis, arthritis, cancer, and neurological diseases. Antioxidants are substances that can neutralize free radicals, thereby reducing the damage to the body. Antioxidants are classified as synthetic and natural antioxidants. Natural products, mainly extracted from some medicinal plants, have strong antioxidant activity and low toxicity and side effects. Moreover, antioxidant activities are also detected in probiotics. Therefore, this chapter summarized the roles of antioxidants and then suggested antioxidants from natural sources have good prospects in the prevention and treatment of various diseases related to oxidative stress. In this study, antioxidant activities were mentioned in plants such as Basella alba, Cistanche sp., and representative probiotics such as Bifidobacterium breve ATCC 15700, Lactobacillus rhamnosus PN04, and Lactococcus lactis PN05 which could serve in DNA damage protection and cytotoxicity oriented for cancer treatment. With the results obtained in these medicinal herbs and probiotics, the antioxidant activities of more and more medicinal herbs and probiotics should be exploited in health care and pharmaceutical product development.

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Section: Representative Probioticsmentioning

confidence: 97%

Medicinal Herbs and Probiotics: Antioxidant Activities for Damaged DNA Protection and Cytotoxicity toward Cancer Treatment

Nguyen

2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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“…EPS are widely used in the food industry as thickeners and gelling additives, which improve food quality and texture [32]. Currently, EPS have received much attention for their antibacterial, anti-oxidative, and anticancer properties, which lead to the development of promising pharmaceutical candidates [33,34]. Since EPS are released into the culture medium, they can be easily recovered and purified [35].…”

Section: Exopolysaccharides (Eps)mentioning

confidence: 99%

Extracellular Metabolites from Industrial Microalgae and Their Biotechnological Potential

2016

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Industrial microalgae, as a big family of promising producers of renewable biomass feedstock, have been commercially exploited for functional food, living feed and feed additives, high-value chemicals in nutraceuticals, cosmeceuticals, and chemical reagents. Recently, microalgae have also been considered as a group that might play an important role in biofuel development and environmental protection. Almost all current products of industrial microalgae are derived from their biomass; however, large amounts of spent cell-free media are available from mass cultivation that is mostly unexploited. In this contribution we discuss that these media, which may contain a remarkable diversity of bioactive substances are worthy to be recovered for further use. Obviously, the extracellular metabolites from industrial microalgae have long been neglected in the development of production methods for valuable metabolites. With the advances in the last ten years, more and more structures and properties from extracellular metabolites have been identified, and the potential utilization over wide fields is attracting attention. Some of these extracellular metabolites can be potentially used as drugs, antioxidants, growth regulators or metal chelators. The purpose of this review is to provide an overview of the known extracellular metabolites from industrial microalgae which might be of commercial interest. The attention mainly focuses on the reports of extracellular bioactive metabolites and their potential application in biotechnology.

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“…Low temperatures lead to increased environmental stress in cells, allowing them to produce more EPS to protect themselves from detrimental environmental conditions [ 18 ]. In addition, EPS extracted from LAB have shown anti-proliferative effects on a variety of cancer cells, such as those associated with the cancer development in the intestine, liver, and cervix [ 19 , 20 ]. Both intracellular and extracellular signals activate the apoptotic pathway, and two different intrinsic and extrinsic pathways correlate with the signal type.…”

Section: Introductionmentioning

confidence: 99%

Heat-Killed Enterococcus faecium KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature

Ha,

Lee,

Paik

2024

J. Microbiol. Biotechnol.

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The anti-cancer effects of heat-killed Enterococcus faecium KU22001 (KU22001), KU22002, and KU22005 isolated from human infant feces were investigated. The anti-proliferative activity of these strains against various cancer cell lines was evaluated using the MTT assay. To determine the production of exopolysaccharides (EPS) with potential anti-cancer effect, ethanol precipitation and phenol-sulfuric acid method was used with the cell free supernatant of strains grown at 25°C or 37°C. The EPS yield of E. faecium strains was higher at 25°C than at 37°C. Among these E. faecium strains, KU22001 grown at 25°C was associated with the highest bax / bcl-2 ratio, effective apoptosis rate, cell cycle arrest in the G 0 /G 1 phase, and condensation of the nucleus in the cervical cancer HeLa cell line. In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.

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Detection on Antioxidant and Cytotoxicity Activities of Exopolysaccharides Isolated in Plant-Originated Lactococcus lactis

Cited by 14 publications

References 13 publications

Medicinal Herbs and Probiotics: Antioxidant Activities for Damaged DNA Protection and Cytotoxicity toward Cancer Treatment

Medicinal Herbs and Probiotics: Antioxidant Activities for Damaged DNA Protection and Cytotoxicity toward Cancer Treatment

Extracellular Metabolites from Industrial Microalgae and Their Biotechnological Potential

Heat-Killed Enterococcus faecium KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature

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