Herein, a novel form of bicomponent nanofiber membrane containing stereo-complex polylactic acid (SC-PLA) was successfully produced by the side-by-side electrospinning of Poly (L-lactic acid) (PLLA) and Poly (D-lactic acid) (PDLA). We demonstrate that through these environmentally sustainable materials, highly efficient nanofiber assemblies for filtration can be constructed at very low basis weight. The physical and morphological structure, crystalline structure, hydrophobicity, porous structure, and filtration performance of the fibrous membranes were thoroughly characterized. It was shown that the fabricated polylactic acid (PLA) side-by-side fiber membrane had the advantages of excellent hydrophobicity, small average pore size, high porosity, high filtration efficiency, low pressure drop as well as superior air permeability. At the very low basis weight of 1.1 g/m2, the filtration efficiency and pressure drop of the prepared side-by-side membrane reached 96.2% and 30 Pa, respectively. Overall, this biomass-based, biodegradable filtration material has the potential to replace the fossil fuel-based polypropylene commercial meltblown materials for the design and development in filtration, separation, biomedical, personal protection and other fields.

Background: Considering transaminase more than the upper limit of normal value as liver injury might overestimate the prevalence of liver involvement in COVID-19 patients. No meta-analysis has explored the impact of varied definitions of liver injury on the reported prevalence of liver injury. Moreover, few studies reported the extent of hypertransaminasemia stratified by COVID-19 disease severity. Methods: A literature search was conducted using PubMed and Embase. The pooled prevalence of liver injury and hypertransaminasemia was estimated. Results: In total, 60 studies were included. The overall prevalence of liver injury was 25%. Compared to subgroups with the non-strict definition of liver injury (33%) and subgroups without giving detailed definition (26%), the subgroup with a strict definition had a much lower prevalence of liver injury (9%). The overall prevalence of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) elevation was 19% and 22%. The prevalence of elevated ALT and AST were significantly higher in severe COVID-19 cases compare to non-severe cases (31% vs 16% and 44% vs 11%). In critically ill and fatal cases, no difference was found in the prevalence of elevated ALT (24% vs 30%) or AST (54% vs 49%). Sensitivity analyses indicated that the adjusted prevalence of ALT elevation, AST elevation, and liver injury decreased to 14%, 7%, and 12%. Conclusion:The overall prevalence of liver injury and hypertransaminasemia in COVID-19 patients might be overestimated. Only a small fraction of COVID-19 patients have clinically significant liver injury. The prevalence of hypertransaminasemia was significantly higher in severe COVID-19 cases compare to non-severe cases. Hence, in severe COVID-19 patients, more attention should be paid to liver function tests.

BackgroundKetamine is an intravenous anesthetic with analgesic effects that has a rapid onset and short duration of action. Many studies have been conducted on the use of ketamine; however, the quantity and quality of such studies have not been reported. Therefore, we aimed to conduct a bibliometric analysis of research on ketamine from 2001 to 2020.MethodsWe used the Web of Science database to get publications on ketamine from January 2001 to December 2020. Various bibliographic information was collected, including the number of publications, year of publication, country of origin, journal name, research hotspots, citation count, and author information.ResultsA total of 5,192 articles were included in the analysis. The United States published the highest number of papers on ketamine and the United States participated in publishing the most papers and disclosure funds. The types of articles in clinical trials were cited more frequently. Most articles on ketamine were published in the journal Anesthesia and Analgesia. Furthermore, the antidepressant effect of ketamine has been a research hotspot for the last 20 years.ConclusionThis study provided a comprehensive analysis of research on ketamine and highlighted the growing interest in ketamine and its antidepressant effects.

The study of climate change impacts on streamflow in small-middle basins within the Upper Yangtze River Basin (UYRB) is not paid enough attention. This paper projected future streamflow changes in the Laixi River basin (LRB), a small-middle basin in the UYRB, during 2041–2100 under RCP2.6, RCP4.5 and RCP8.5 by coupling SDSM and SWAT. The results indicate that the temperature and precipitation in the LRB show a fluctuating upward trend, and the change is most severe under RCP8.5. The increase of maximum temperature is larger than that of minimum temperature. The precipitation changes in May to September are relatively greater than in other months, while temperature is the opposite. More importantly, the streamflow is projected to rise gradually during the whole period. Under RCP2.6, increases of streamflow in the 2050s are greater than in the 2080s, while it is the opposite under RCP4.5 and RCP8.5. The increase in high flow from May to August is expected to be significantly higher than the low flow from September to April. Although the study is focused on the LRB, the results gained can provide a reference for other small-middle basins in the UYRB and all basins experiencing subtropical monsoon humid climate.

Climate change affects water cycle in different regions. The response of annual runoff and seasonal distribution to climate change in the upper reaches of the Minjiang River during 2021–2050 was studied by coupling the Statistical Downscaling Model (SDSM) and the Soil and Water Assessment Tool (SWAT). This model was driven by the second-generation Canadian Earth System Model (CanESM2) under RCP2.6, RCP4.5, and RCP8.5 scenarios. The results show that the runoff in the upper reaches of the Minjiang River has a unique response to climate change. The maximum and minimum temperatures will increase with the increase in emissions, especially in December–January. The daily precipitation shows an upward trend, especially in July–August in the RCP4.5 scenario. The annual runoff shows an upward trend with the increase in emissions. Compared with the current increase of 13–26%, the most prominent period is November–April. Because the study area covers high mountains and gorge landforms, the altitude difference is great, and the influence of evapotranspiration and snow melting processes is more prominent, causing the monthly runoff to decrease in June–July with an increase in precipitation. From April to May, precipitation decreased while runoff increased.

BackgroundThe neurotoxicity effects of anesthetic exposure on the developing brain have been one of the current research hotspots and numerous articles were published in the past decades. However, the quality and comparative information of these articles have not been reported. This research aimed to provide a comprehensive overview of the current state of the field by investigating research hotspots and publication trends concerning the neurotoxicity of anesthesia in the developing brain.Materials and methodsOn 15 June 2022, we searched articles on the neurotoxicity of anesthesia in the developing brain through the Science Citation Index databases from 2002 to 2021. Data of the author, title, publication, funding agency, date of publication, abstract, type of literature, country, journal, keywords, number of citations, and research direction were collected for further analysis.ResultsWe searched and analyzed 414 articles in English on the field of neurotoxicity of anesthesia in the developing brain from 2002 to 2021. The country with the largest number of publications was The United States (US) (n = 226), which also had the largest total number of citations (10,419). Research in this field reached a small peak in 2017. Furthermore, the largest number of articles were published in three journals, Anesthesiology, Anesthesia and Analgesia, and Pediatric Anesthesia. The top 20 articles that were cited most often were studied. In addition, the top hotspots of this area in clinical investigations and basic research were analyzed separately.ConclusionThis study provided an overview of the development in the neurotoxicity of anesthesia in the developing brain using bibliometric analysis. Current clinical studies in this area were mainly retrospective; in the future, we should place more emphasis on prospective, multicenter, long-term monitoring clinical studies. More basic research was also needed on the mechanisms of neurotoxicity of anesthesia in the developing brain.

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This study was funded by Beijing Municipal Administration of Hospitals' Youth Programme (QML20200102) to HHM Conflict of interest:None declared Background:Mechanical ventilation can lead to cardiopulmonary complications in elderly patients undergoing abdominal surgery plus general anesthesia. The cardiopulmonary exercise test (CPET) is a dynamic and noninvasive evaluation method for assessing the cardiopulmonary system function under rest and stress. Positive end-expiratory pressure (PEEP) titration guided by electrical impedance tomography (EIT) can individualize lung protection strategies and may be beneficial in postoperative cardiopulmonary exercise capacity for these patients. Material/Methods:This study is a prospective, single-center, randomized, and controlled trail that will include 80 elderly patients scheduled for major abdominal surgery. The patients will be divided into 2 groups: (1) intervention group: using individualized PEEP ventilation; and (2) control group: using fixed PEEP ventilation (3-5 cmH 2 O). Results:The primary outcome is the change of postoperative cardiopulmonary exercise capacity. Conclusions:In this study, we will evaluate if EIT-guided PEEP titration can improve postoperative cardiopulmonary exercise capacity and reduce postoperative complications in elderly patients undergoing open abdominal surgery plus general anesthesia. If the result is in accordance with the hypothesis, it would provide evidence to aid the perioperative management for these patients.