The lower serum IL-10 in our subjects fulfilling IBS Rome II symptom criteria suggests an altered immune regulation. Further studies are needed to elucidate if a lower serum IL-10 may be useful as a biomarker for IBS in the Mexican population, especially for women with IBS-D.
Background: there has been recent evidence of an alteration in irritable bowel syndrome (IBS) immune regulation, as well as variations in cytokine polymorphisms.Aims: to determine the frequency of the IL-10 (-1082G/A) and TNF-α (-308G/A) polymorphisms in subjects with IBS in Mexico.Methods: volunteers answered the Rome II Questionnaire and were classified as IBS (n = 45) and controls (n = 92). The IBS subjects were then categorized as IBS-D: 22.2 %, IBS-C: 28.9 %, and IBS-A/M: 48.9 %. The polymorphism frequency among groups was compared.Results: there were no differences between IBS vs. controls in the frequency of the high (8.9 vs. 18.5 %), intermediate (60.0 vs. 57.6 %), or low (23.9 vs. 38.9 %) producer IL-10 genotypes, p = 0.315. Neither were there differences in the high (0 vs. Conclusions: in this group of volunteers in Mexico, the frequency of the IL-10 (-1082G/A) and TNF-α (-308G/A) genotypes was similar in IBS and controls. However, there was a greater frequency of the low producer of IL-10 in those subjects with IBS-D, suggesting a genetic predisposition to abnormal immune regulation due to a lower anti-inflammatory component in this subgroup.
Objective: To review the results and rotational stability of the enVista MX60T TORIC intraocular lens. Methods: A prospective and longitudinal study was carried out; phacoemulsification surgery was performed with MX60T toric lens implantation. At week one, month one and month three, uncorrected visual acuity (UCVA) and spherical equivalent were evaluated. At each visit, the alignment of the toric lens was evaluated using the OPD-Scan III "toric summary" (Refractive Power/Corneal Analyzer, NIDEK ® ). Results: Twenty eyes (n = 20) were included. Mean preoperative uncorrected visual acuity (UCVA) was 0.84 logMAR, and at the final visit UCVA was 0.004 logMAR (p <0.0001). Mean preoperative corneal astigmatism was -2.50 diopters; at the final visit mean refractive astigmatism was -0.34 diopters (p <0.0001). Ninety percent of the eyes had a final vision of 20/25 or better. The average rotation of the lens was 2.05° with a range of 0-5. There was no relationship between the axial length and the amount of lens rotation (p <0.40). Final UCVA was related to the degree of final astigmatism (p = 0.001). None of the eyes showed glistening or required posterior YAG capsulotomy. Conclusions: The enVista MX60T toric intraocular lens showed good visual results and excellent rotational stability in the mid-term (3 months). Therefore, it can be considered as an excellent therapeutic option in patients with cataract and regular corneal astigmatism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.