Lower Serum IL-10 Is an Independent Predictor of IBS Among Volunteers in Mexico

Schmulson, Max; Pulido‐London, Daniela; Rodríguez, O. Esparcia; Morales-Rochlin, Norma; Martínez-García, Rosalinda; Gutiérrez-Ruı́z, Ma.Concepción; López-Alvarenga, Juan Carlos; Robles-Dı́az, Guillermo; Gutiérrez-Reyes, Gabriela

doi:10.1038/ajg.2011.484

Cited by 54 publications

(56 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a convincing history of enteritis with onset of IBS is present only in a subset of patients with IBS (Jeffery, Quigley, Öhman, Simrén, & O'Toole, 2012). The literature reveals inconsistencies as to whether pro-and/or anti-inflammatory cytokines are altered in IBS patients (Chang et al, 2012;Schmulson et al, 2012). It is our hypothesis that in adults with IBS in whom the etiology may be due to dysbiosis, an elevation in serum anti-and pro-inflammatory cytokines may signal either a state of chronic immune stimulation and/or an alteration in cytokine signaling pathways.…”

Section: Immune Functionmentioning

confidence: 99%

Update on Irritable Bowel Syndrome Program of Research

2013

View full text Add to dashboard Cite

Purpose: This article provides an update and overview of a nursing research program focused on understanding the pathophysiology and management of irritable bowel syndrome (IBS). Methods: This review includes English language papers from the United States, Europe, and Asia (e.g., South Korea) from 1999 to 2013. We addressed IBS as a health problem, emerging etiologies, diagnostic and treatment approaches and the importance of a biopsychosocial model. Results: IBS is a chronic, functional gastrointestinal disorder characterized by recurrent episodes of abdominal pain and alterations in bowel habit (diarrhea, constipation, mixed). It is a condition for which adults, particularly women ages 20-45, seek health care services in both the United States and South Korea. Clinically, nurses play key roles in symptom prevention and management including designing and implementing approaches to enhance the patients' self-management strategies. Multiple mechanisms are believed to participate in the development and maintenance of IBS symptoms including autonomic nervous system dysregulation, intestinal inflammation, intestinal dysbiosis, dietary intolerances, alterations in emotion regulation, heightened visceral pain sensitivity, hypothalamic-pituitary-adrenal dysregulation, and dysmotility. Because IBS tends to occur in families, genetic factors may also contribute to the pathophysiology. Patients with IBS often report a number of co-morbid disorders and/or symptoms including poor sleep. Conclusion: The key to planning effective management strategies is to understand the heterogeneity of this disorder. Interventions for IBS include non-pharmacological strategies such as cognitive behavior therapy, relaxation strategies, and exclusion diets.

show abstract

Section: Immune Functionmentioning

confidence: 99%

Update on Irritable Bowel Syndrome Program of Research

2013

View full text Add to dashboard Cite

show abstract

“…Several investigators have reported reduced levels of serum anti-inflammatory cytokine IL-10 12,13 or no difference between those with IBS and controls. 14 The aim of the current study is to determine whether measures such as nighttime ANS balance, lactulose/mannitol ratio (intestinal permeability measure), and serum IL-10, identified in the literature as potential markers in IBS, are predictive of outcomes with a cognitively-focused behavioral therapy.…”

mentioning

confidence: 99%

Balance of Autonomic Nervous System Predicts Who Benefits from a Self-management Intervention Program for Irritable Bowel Syndrome

Jarrett

Cain

Barney

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsTo determine if potential biomarkers can be used to identify subgroups of people with irritable bowel syndrome (IBS) who will benefit the most or the least from a comprehensive self-management (CSM) intervention. MethodsIn a two-armed randomized controlled trial a CSM (n = 46) was compared to a usual care (n = 46) group with follow-up at 3 and 6 months post randomization. Biomarkers obtained at baseline included heart rate variability, salivary cortisol, interleukin-10 produced by unstimulated peripheral blood mononuclear cells, and lactulose/mannitol ratio. Linear mixed models were used to test whether these biomarkers predicted improvements in the primary outcomes including daily abdominal pain, Gastrointestinal Symptom score and IBS-specific quality of life. ResultsThe nurse-delivered 8-session CSM intervention is more effective than usual care in reducing abdominal pain, reducing Gastrointestinal Symptom score, and enhancing quality of life. Participants with lower nighttime high frequency heart rate variability (vagal modulation) and increased low frequency/high frequency ratio (sympathovagal balance) had less benefit from CSM on abdominal pain. Salivary cortisol, IL-10, and lactulose/mannitol ratio were not statistically significant in predicting CSM benefit. Baseline symptom severity interacts with treatment, namely the benefit of CSM is greater in those with higher baseline symptoms. ConclusionsCognitively-focused therapies may be less effective in reducing abdominal pain in IBS patients with higher sympathetic tone. Whether this a centrally-mediated patient characteristic or related to heightened arousal remains to be determined.

show abstract

“…There is evidence of sustained inflammation in IBS supported by numerous studies that have detected low anti-inflammatory cytokines in IBS patients [35] or others that found high levels of those pro-inflammatory ones or a misbalance of the pro-and anti-inflammatory cytokine proportion [36,37]. The complex dialogue between the structures involved in maintaining the homeostasis includes interrelation of nervous, immune, and endocrine systems [30,34], where a pivotal piece is the brain that governs the humoral and neurological systems [34,38,39], in a complex network with multidirectional communicating systems [10].…”

Section: Inflammation In Ibsmentioning

confidence: 72%

Inflammation as a Potential Therapeutic Target in IBS

Chira¹,

Chira²,

Dumitraşcu³

2016

Irritable Bowel Syndrome - Novel Concepts for Research and Treatment

View full text Add to dashboard Cite

The pathogenesis of irritable bowel syndrome (IBS) has been intensively researched, and despite a long journey for unraveling all the structures and the pathways involved, it still remains partially obscure. Inflammation was the first to be hypothesized as a potential pathway for the pathogenesis of IBS. It remains a keystone in the complex machinery of the pathogenesis that is currently considered multifactorial. Elucidating the pathogenesis of IBS is crucial for a targeted therapy of the disease. In this chapter, we review information regarding gut inflammation in IBS, underlining some of the newest data or the cornerstones. Additionally, our aim was also to review treatment currently available and future perspectives regarding anti-inflammatory treatments for IBS. Newer techniques allow detection and research of mediators involved in inflammation, as well as their potential role to be targeted by pharmacological agents. Recent data supports not only further research of the newer agents that are currently being developed but also some of the available ones that do not have sufficient evidence. Emerging therapies that target inflammation are under evaluation, in trials. A multidrug or a multidisciplinary approach needs to be considered in some cases that fail to respond to current treatment.

show abstract

Lower Serum IL-10 Is an Independent Predictor of IBS Among Volunteers in Mexico

Abstract: The lower serum IL-10 in our subjects fulfilling IBS Rome II symptom criteria suggests an altered immune regulation. Further studies are needed to elucidate if a lower serum IL-10 may be useful as a biomarker for IBS in the Mexican population, especially for women with IBS-D.

Cited by 54 publications

References 35 publications

Update on Irritable Bowel Syndrome Program of Research

Update on Irritable Bowel Syndrome Program of Research

Balance of Autonomic Nervous System Predicts Who Benefits from a Self-management Intervention Program for Irritable Bowel Syndrome

Inflammation as a Potential Therapeutic Target in IBS

Contact Info

Product

Resources

About