CoelhoCoelho Coelho Coelho Coelho O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de barbatimão na cicatrização de feridas cutâneas em ratos O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de barbatimão na cicatrização de feridas cutâneas em ratos barbatimão na cicatrização de feridas cutâneas em ratos barbatimão na cicatrização de feridas cutâneas em ratos barbatimão na cicatrização de feridas cutâneas em ratos barbatimão na cicatrização de feridas cutâneas em ratos Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing in rats in rats in rats in rats in rats JULICE Todos foram submetidos à ligadura da veia femoral direita para produzir hipertensão venosa. Após 30 dias foi confeccionada a ferida cutânea. Dividiu-se os animais em quatro grupos. O grupo S recebeu aplicação tópica de sulfadiazina de prata; o grupo IR, extrato de ipê-roxo; o grupo B, extrato de barbatimão e o grupo C, aplicação de solução salina a 0,9%, diariamente, nas feridas por um período de sete, 14 e 30 dias. A análise histológica avaliou: proliferação vascular, neutrófilos, linfócitos, fibroblastos, fibras colágenas e epitelização. Resultados:Resultados: Resultados: Resultados: Resultados: Os achados macroscópicos mostraram epitelização completa aos 14 dias em todos os animais dos grupos S, IR e B. Na análise histológica aos 14 dias, apenas o grupo C ainda apresentava epitelização incompleta em seis animais; neste mesmo período houve diferença estatisticamente significativa entre o grupo controle e os demais grupos quanto ao processo inflamatório e neovascularização. Em relação à presença de fibroblastos e colágeno, houve diferença estatisticamente significativa entre o grupo controle e os demais grupos aos 30 dias. No tratamento de feridas tem-se intensificado a pesquisa de produtos naturais para auxiliar a cicatrização, como o óleo de copaíba, papaína, vitamina A [3][4][5] . Na medicina popular são usados muitos extratos de plantas para o tratamento de diversos tipos de doenças. Entre as milhares de plantas medicinais brasileiras, os ipês, também...

Purpose:To evaluate axonal regeneration after end-to-side nerve repair with fibrin glue in rats. Methods: Forty-five Wistar rats were divided into three groups: group A (n=15), were not submitted to surgery (control group); group B (n=15) were submitted to fibular transection without repair; and group C (n=15), were submitted to fibular transection with end-to-side nerve anastomosis using fibrin glue, in the lateral surface of an intact tibial nerve. The three groups were submitted to walking track (30 and 90 days) and posterior morphometrical analysis (90 days). Results: The functional tests demonstrated that there was no difference in the walking track during the study in group A (p>0.05). The group B had walking pattern impairment in the two tests (p>0.05). The group C had walking pattern impairment in the first test, with important recovery in the second test (p<0.05). The morphometrical assessment revealed significantly higher number of regenerated mielinates axons in group C, compared to group B (p<0.05). Conclusion: The end-to-side nerve repair with fibrin glue shows axonal recovery, demonstrated through functional and morphometrical ways in rats. Key words: Suture Techniques. Fibrin Tissue Adhesive. Microsurgery. Rats. RESUMOObjetivo: Avaliar a regeneração axonal após anastomose nervosa término-lateral (ATL) usando cola de fibrina em ratos. Métodos: Quarenta e cinco ratos Wistar distribuídos em três grupos: os animais do grupo A (n=15) não foram submetidos à secção nervosa (grupo controle); os animais do grupo B (n=15) foram submetidos apenas à secção do nervo fibular, sem posterior anastomose; e os animais do grupo C (n=15) foram submetidos à secção do nervo fibular e à ATL com cola de fibrina no nervo tibial. Posteriormente, os animais foram submetidos a dois testes de marcha (30 e 90 dias) e à análise morfométrica (90 dias). Resultados: A análise estatística dos testes de marcha demonstrou que o grupo A não apresentou alteração no padrão de caminhada durante o estudo (p>0,05). O grupo B apresentou prejuízo motor no primeiro e no segundo teste (p>0,05). O grupo C apresentou um padrão de atrofia no primeiro teste, com recuperação da marcha no segundo teste (p<0,05). Na análise morfométrica, o grupo C apresentou regeneração axonal significativamente superior ao grupo B (p<0,05). Conclusão: A ATL realizada com cola de fibrina resultou em regeneração axonal no rato, demonstrada tanto histologicamente quanto funcionalmente. Descritores: Técnicas de Sutura. Adesivo Tecidual de Fibrina. Microcirurgia. Ratos.

OBJECTIVE: To compare sleepiness scores of the Epworth scale in patients with different levels of arterial pressure when undergoing outpatient monitoring within the context of clinical evaluation. METHODS: A total of 157 patients selected for outpatient monitoring of arterial pressure during hypertension evaluation were divided into 3 groups: group 1 - normotensive; group 2 - hypertensive; group 3 - resistant hypertensive. For analysis, values > or = 11 were considered as associated with respiratory disturbances during sleep. RESULTS: Seventeen (10.8%) patients in group 1, 112 (71.3%) in group 2, and 28 (17.8%) in group 3, which was composed of aged, more severely hypertensive individuals, were analyzed. Groups were similar relative to sex and body mass index, but different in relation to systolic and diastolic pressure levels and age. Despite an absolute difference, no statistically significant difference occurred between Epworth scores and in the proportion of patients with values > or = 11 (5.9% vs. 18.8% vs. 212.4%; P=0.37). Despite the positive association between degree of sleepiness measured with the scale and the severity of the hypertension, no statistical significance occurred following control by age (p=0.18). CONCLUSION: A positive correlation exists between degree of sleepiness and hypertension severity. The absence of a statistical significance shown in the present study could be due to a beta type of error. Instruments that render this complaint into an objective finding could help in the pursuit of an investigation of respiratory disturbances during sleep in more severely hypertensive patients, and should therefore be studied better

Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.

PURPOSE:To determine the effects of end-to-side nerve repair performed only with fibrin glue containing nerve growth in rats. METHODS:Seventy two Wistar rats were divided into six equal groups: group A was not submitted to nerve section; group B was submitted to nerve fibular section only. The others groups had the nerve fibular sectioned and then repaired in the lateral surface of an intact tibial nerve, with different procedures: group C: ETS with sutures; group D: ETS with sutures and NGF; group E: ETS with FG only; group F: ETS with FG containing NGF. The motor function was accompanied and the tibial muscle mass, the number and diameter of muscular fibers and regenerated axons were measured. RESULTS:All the analyzed variables did not show any differences among the four operated groups (p>0.05), which were statistically superior to group B (p<0.05), but inferior to group A (p>0.05). CONCLUSION:The end-to-side nerve repair presented the same recovery pattern, independent from the repair used, showing that the addition of nerve growth factor in fibrin glue was not enough for the results potentiating.Key words: Suture Techniques. Fibrin Tissue Adhesive. Microsurgery. Rats. RESUMO OBJETIVO:Determinar os efeitos do reparo nervoso término-lateral realizado apenas com cola de fibrina contendo fator de crescimento nervoso em ratos. MÉTODOS:Setenta e dois ratos Wistar foram distribuídos em seis grupos: A -não submetido à secção nervosa; B -secção do nervo fibular (sem reparo); Os outros grupos tiveram o nervo fibular seccionado e então reparado na superfície lateral do nervo tibial

A 14-year-old female patient became pregnant 6 years after heart transplantation. The pregnancy evolved uneventfully, and the newborn infant was healthy. Five months after delivery, the mother was in good condition with preserved ventricular function, and the baby had normal neuro-psychomotor development. Even though the case reported here was a success, pregnancy following cardiac transplantation is considered a high-risk condition and remains contraindicated.

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Summary:Generally, the main complications of silicone implantation are local symptoms. However, some patients develop late-onset systemic symptoms often associated with a rare form of hyperactive immune response, as part of a syndrome known as autoimmune syndrome induced by adjuvants (ASIA). Reported cases of ASIA have shown resolution with explantation, but not with immunomodulatory therapy. In this report, we described a case of a previously healthy 23-year-old woman, who has undergone silicone breast implant augmentation, for aesthetic reasons, and developed localized cutaneous impairment 3 years postsurgery. She received a diagnosis of ASIA with a new presentation: Lupus-like manifestation through localized cutaneous impairment. This patient’s symptoms were managed without the need for surgical intervention, which has not been previously reported, because the patient did not want an explantation for aesthetic reasons. The patient was started on hydroxychloroquine, 400 mg per day, and remains asymptomatic after 2 years of treatment. The exact predisposition to ASIA is still unknown. Without implant explantation and with immunomodulatory treatment, this patient’s condition substantially improved. Based on our current understanding of this disease, it might not be prudent to indicate breast augmentation with silicone implants in patients with documented autoimmune reaction to an adjuvant, an established autoimmune condition, or genetic predisposition. However, if a patient does develop silicone-induced ASIA, explantation is no longer the only successfully reported option, as these symptoms can be managed with immune suppression.