Background: This study aimed to evaluate cognition in patients with alcohol dependence. During the past decade, there has been an increasing interest in the evaluation of cognitive function in substance use disorders. Substance use includes the use of licit substance such as alcohol, tobacco, and diversion of drugs as well as illicit substances. Alcohol in beverage form is among the most widely used psychoactive drugs in the world, and it has dependence-producing properties. Ethanol in alcohol is a chemical and after consumption has a multitude of effects. Aims and Objectives: The aim of this study was to assess the cognitive functions in patients with alcohol dependence as compared to the normal controls using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Materials and Methods: This study included 44 patients with alcohol dependence diagnosed as per international classification of disease tenth edition criteria with a mean age of 43.61 ± 7.38. Cognition was tested using a sensitive battery of psychometric testing MMSE and MoCA. Results: Compared with healthy controls (n = 44), patients had lower total scores of cognitive testing MMSE (P = 0.010) and MoCA (P = 0.000). Conclusion: Our results indicted cognitive impairment in patients with alcohol dependence. This is important to determine prognosis and managing patients.
Ayurveda has a holistic approach towards lifestyle disorders. In Ayurveda there are many diseases which are caused due to management of lifestyle. The burden of these lifestyle disorders is increasing day by day in the society. There are many etiological factors which cause lifestyle disorders. The life style disorders considered in Ayurveda are Sthaulya (obesity), Premeh (diabetes), Asthisandhigahta roga (musculoskeletal disorders), Rakatgata vata (Hypertension), Hridyaroga (coronary artery diseases), cancer, physco somatic disorders (Alzheimer's disease), Kalibhata, Bandya (infertility) etc. These all disease is having lifestyle management causes for which they are taken under lifestyle disorders. They are rising in the society due to modernization, affluence of science technological development which leads to more sedentary life styles, which disturb the physical, mental and social well being of an individual. In Ayurveda the main cause of any disease is improper functioning of the Dosha and Dhatus. And they are disturbed by the etiological factors which influence them. Tridoshas are influenced by both Aahar Vihar etiological factors. In addition to these etiological factors there is a main factor which cause lifestyle disorders is stress. All these factors which are responsible for the disturbance of Tridoshas and Dhatus are the main cause for life style disorders.
In Ayurveda, it is regarded as Medoroga which includes fat tissue and fat metabolism, results from the excessive accumulation of Meda (fat/ adipose tissue) and Mamsa (flesh/ muscle tissue) leading to flabbiness of hips, abdomen, and breast. It is considered as Santarpanottha Vikara and counted one among the Ashtnindita Purusha by Ayurvedic Acharayas. According to Ayurveda, Sthoulya begins with an imbalance of Doshas (Vata, Pitta and Kapha), Agni (digestive fire), Malas (waste products) or an imbalance of Srotas (microcirculatory channels). This collection of imbalances then interferes with the formation of tissues or Dhatus and leads to a tissue imbalance that we experience as Sthoulya. It is most prevailing condition being faced by majority of the population, but yet among the most neglected health problem in the world. In this regard approach of this study is to give safer, comprehensive and rational option for treating Sthaulya (Obesity) and this is a humble attempt to probe into the different pathophysiological aspects behind Sthaulya, taking into consideration the classical therapy coupled with modern interpretations. Amritadya Guggulu by the virtue of its Rasapanchaka (Rasa- Katu, Tikta, Kashaya, Guna- Laghu, Ruksha and Virya- Ushna, Vipaka- Katu, Dosha Karma- Kapha Vatashamaka) is effective in the management of Sthoulya including all Kapha predominant pathologies, leading to Samprapti Vigatana of Sthoulya. Hence this study is carried out to establish the efficacy of the treatment considering the clinical and laboratory profile of obesity (Sthoulya). The study was done on 30 patients taken from both IPD & OPD of RGGPG Ayurvedic College and Hospital, Paprola, H.P. The duration of the trial was 60 days with follow up of 15 days and the observations obtained are analyzed statistically after the end of the study.
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