Because
of their commanding properties, ultrashort and short peptides
are gaining significance as viable candidates for molecular self-assembly,
which is a naturally inspired approach for developing supramolecular
structures and can be used to design various strategies of significance
in the field of biomaterials. Self-assembly of biomolecules like proteins,
lipids, and nucleic acids is observed in living organisms, various
biological-process-based examples like amyloid-β plaque formation,
lipid bilayer assembly, and the complementary binding of the nucleotide
bases of nucleic acids involve self-assembly. Among all biomolecules,
peptide-based self-assembly has the advantage of the availability
of the source, peptides can be easily synthesized or obtained from
the natural degradation process and can be engineered to modulate
their action, making them an area of immense interest for research.
Multiple modification options provide a wide area for the engineering
of amino acid sequences. Understanding of the amino acid residues
with their existing properties and modified properties is very helpful
for further improvements. Computational approaches like molecular
dynamics simulations provide atomistic-level insight into the self-assembly
process, by which newer physical-chemical modifications can be planned.
Virtual screening of the peptides on the basis of their properties
and probability for the desired activity are helpful as well. Engineered
and programmed peptides have been reported for various applications
like drug delivery and target specific formulations. A combined approach
of computational and experimental studies is helpful to understand
and optimize the self-assembly process and mechanism at the atomic
level. These self-assembled ultrashort peptides have been used in
a wide range of applications from hydrogels to drug delivery agents,
biosensors, emulsifiers, and so on.
The leaves of Catharanthus roseus (L.) G. Don contain a large number of diverse secondary metabolites, making them comparably complex. The Catharanthus genus has received increased interest from scientists in recent years due to its extensive applications in several domains, including the pharmaceutical sector, where precise characterization of its characteristics is required. An effective inquiry technique is needed for chemo-profiling to identify the metabolites in plant samples. The main goal of this research is to provide supplementary data on the chemical composition of the leaves of twenty-five different accessions of C. roseus through the application of gas chromatography-mass spectrometry (GC-MS). The study’s findings reveal the existence of a vast number of phytochemicals, allowing for a comparison of the different accessions. Furthermore, a meticulous statistical analysis of this data using principal components analysis (PCA) and a heatmap, and hierarchical cluster analysis (HCA) may aid in providing more relevant information on C. roseus leaves for possible investigation of their metabolites in further scientific studies.
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