: Lack of adequate sleep is a major source of many harmful diseases related to heart, brain, psychological changes, high blood pressure, diabetes, weight gain etc. The 40 to 50 % of the world’s population is suffering from poor or inadequate sleep. Insomnia is a sleep disorder in which individual complaint of difficulties in starting/continuing sleep at least four weeks regularly. It is estimated that 70% of the heart diseases are generated during insomnia sleep disorder. The main objective of this study to determine the all work conducted on insomnia detection and to make a database. We used two procedures including network visualization techniques on two databases including PubMed and Web of Science to complete this study. We found 169 and 36 previous publications of insomnia detection in the PubMed and the Web of Science databases, respectively. We analyzed 10 datasets, 2 databases, 21 genes, and 23 publications with 30105 subjects of insomnia detection. This work has revealed the future way and gap so far directed on insomnia detection and has also tried to provide objectives for the future work to be proficient in a scientific and significant manner.

Lack of sleep causes many sleep disorders such as nocturnal frontal lobe epilepsy, narcolepsy, bruxism, sleep apnea, insomnia, periodic limb movement disorder, and rapid eye movement behavioral disorder. Out of all, bruxism is a common behavior, which is found in 8-31% of the population. Bruxism is a sleep disorder in which individuals involuntarily grinds and clenches the teeth. The main aim of this work is to detect sleep bruxism by analyzing the electroencephalogram (EEG) spectrum analysis of the change in the domain of different stages of sleep. The present research was performed in different stages such as collection of the data, preprocessing of the EEG signal, analysis of the C4-P4 and C4-A1 channels, comparison between healthy humans and bruxism patients, and classification using decision tree method. In this study, the channels C4-P4 and C4-A1 of the EEG signal were combined for the detection of bruxism by using Welch technique, which mainly focused on two sleep stages such as S1 and rapid eye movement. The total number of EEG channels of healthy humans and bruxism patients analyzed in this work were 15 and 18, respectively. The results showed that the individual accuracy of the C4-P4 and C4-A1 channels was 81.70% and 74.11%, respectively. The combined accuracy of both C4-P4 and C4-A1 channels was 81.25%. The specificity of combined result was higher than individual. In addition, the value of theta activity during detection is consistent throughout the period, and the accuracy of S1 stage is better than rapid eye movement stage. We proposed that the theta activity of S1 could be taken for the detection of bruxism. The proposed approach in the detection of the bruxism is negligible in noise as it is in mathematical form and has taken very less time as compared with the traditional systems. The present research work would provide a fast and effective detection system of the sleep bruxism with high accuracy for medical big data applications. INDEX TERMS Decision tree, machine learning classifier, neurological disorder, scalp EEG, sleep bruxism.

Bruxism is a sleep syndrome, in which individual involuntarily grinding and clenching the teeth. If sleep does not complete properly, then it generates many disorders such as bruxism, insomnia, sleep apnea, narcolepsy, rapid eye movement behavioral disorder, and nocturnal frontal lobe epilepsy. The aim of this paper is to draw the results in the form of signal spectrum analysis of the changes in the domain of different stages of sleep. The present research completed in three stages such as the collection of the data, analysis of the electroencephalogram (EEG) signal, and comparative analysis between bruxism patients and normal subjects. Importantly, the channels EMG1-EMG2 and ECG1-ECG2 of the EEG signal were combined for the prognosis of bruxism by using power spectral density, which mainly focused on two sleep stages such as wake (W) and rapid eye movement (REM). The total number of one-minute EEG recordings from bruxism patients and normal subjects analyzed in this work were 149 and 95, respectively. The obtained results show that the average normalized values of the power spectral density of the EMG1-EMG2 and ECG1-ECG2 channels during REM and W sleep stages are several folds higher in case of the bruxism than those in the normal. Moreover, the proposed power spectral density-based method by using the decision tree classifier shows a higher accuracy for the prognosis of sleep bruxism in comparison with previous works. In addition, the proposed approach in the prognosis of the bruxism is noise free and accurate as it is in mathematical form and has taken very less time as compared with the traditional systems. The present research work would provide a fast and effective prognosis system of the human bruxism with high accuracy for medical applications.INDEX TERMS Bruxism, decision tree (DT), electroencephalogram (EEG), electrocardiogram (ECG), electromyogram (EMG), power spectral density, sleep disorder.

High-frequency oscillations (HFOs) of 80∼500 Hz in the intracranial electroencephalogram (iEEG) recordings are considered as a reliable marker for epileptic location. However, a significant challenge to the clinical use of HFOs is due to the time-consuming procedure of visually identifying them. A new methodology is presented in this paper for the automated detection of HFOs based on their 2D time-frequency map employing the short-time energy (STE) estimation and the convolutional neural network (CNN) classification algorithm. The effectiveness and usefulness of the proposed method are evaluated using the clinical iEEG data acquired from five patients (28.4 ± 13.0 years) with medically intractable epilepsy. The proposed methodology presents the following significant advantages: 1) compared with the recently reported HFOs detector based on the CNN using only the 1D temporal EEG signal, the proposed method achieves a higher accuracy using the deep CNN classifier on 2D time-frequency map of HFOs, of which the evaluated sensitivity and false discovery rate (FDR) for identifying ripples are 88.16% and 12.58%, respectively, and the corresponding sensitivity and FDR are 93.37% and 8.1% for detecting fast ripples, respectively; 2) it is capable of automatically extracting the shared features of HFOs events of different patients and would be much robust, unlike other automated methodologies proposed in the literature where the characteristics of HFOs were extracted manually on the basis of researchers' knowledge, which, probably, is prone to observer bias; and 3) with the proposed STE estimation, all suspicious ripples and fast ripples could be initially found out and transformed into time-frequency map for subsequently CNN-based classification, rather than transforming and classifying the raw data, thus requiring a lower computational resource. In addition, the time occurrence of each transient event of the HFOs can be identified to be potentially useful for further seizure analysis. In conclusion, this automated detection of the HFOs combing the STE and the CNN could allow analyzing large amounts of data in a short time while assuring a relatively higher accuracy and, thus, would potentially serve to provide a clinically useful tool.INDEX TERMS Convolutional neural networks (CNNs), epilepsy, high frequency oscillations (HFOs), intracranial electroencephalograms (iEEG), short time energy (STE).

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Early risk identification of an unexpected sudden cardiac death (SCD) in a person who is suffering malignant ventricular arrhythmias is highly significant for timely intervention and increasing the survival rate. For this purpose, we have presented an automated strategy for prediction of SCD with a high-level accuracy by using measurable arrhythmic markers in this paper. The set of arrhythmic parameters includes three repolarization interval ratios, such as T p T e /QT, JT p /JT e , and T p T e /JT p and two conduction-repolarization markers, such as T p T e /QRS and T p T e /(QT×QRS). Each of them is calculated directly from the detected QRS complex waves and T-wave of electrocradiogram (ECG) signals. Then, all calculated markers are used for the automatical classification of normal and SCD risk groups by employing machine learning classifiers, such as k-nearest neighbor (KNN), decision tree (DT), Naive Bayes (NB), support vector machine (SVM), and random forest (RF). The effectiveness and usefulness of the proposed method is evaluated using a database of measured ECG data acquired from 28 SCD and 18 normal patients. For the automated strategy, the set of five arrhythmic risk markers can predict SCD in less than one second with an average accuracy of 98.91% (KNN), 98.70% (SVM), 98.99% (DT), 97.46% (NB), and 99.49% (RF) for 30 minutes before the occurrence of SCD. Moreover, a practical and straightforward SCD index (SCDI) through a judicious integration of these markers is also proposed by using the Student's t-test. The obtained SCDIs are 1.2058 ± 0.0795 and 1.7619 ± 0.1902 for normal and SCD patients, respectively, which provide a sufficient discrimination degree with a p-value of 6.5061e-35. The present results show that both the automated classifier and the integrated SCDI can predict the SCD up to 30 minutes earlier, and that these predictions could be more practical and efficient if applied in portable smart devices with real-time requirements in hospital settings or at home.

Sphingosine kinase 1 (SphK1) is a promising therapeutic target against several diseases including mammary cancer. The aim of present work is to identify a potent lead compound against breast cancer using ligand-based virtual screening, molecular docking, MD simulations, and the MMPBSA calculations. The LBVS in molecular and virtual libraries yielded 20,800 hits, which were reduced to 621 by several parameters of drug-likeness, lead-likeness, and PAINS. Furthermore, 55 compounds were selected by ADMET descriptors carried forward for molecular interaction studies with SphK1. The binding energy (DG) of three screened compounds namely ZINC06823429 (-11.36 kcal/mol), ZINC95421501 (-11.29 kcal/mol), and ZINC95421070 (-11.26 kcal/mol) exhibited stronger than standard drug PF-543 (-9.9 kcal/mol). Finally, it was observed that the ZINC06823429 binds tightly to catalytic site of SphK1 and remain stable during MD simulations. This study provides a significant understanding of SphK1 inhibitors that can be used in the development of potential therapeutics against breast cancer.

Bruxism is a sleep disorder in which the patient clinches and gnashes their teeth. Bruxism detection using traditional methods is time-consuming, cumbersome, and expensive. Therefore, an automatic tool to detect this disorder will alleviate the doctor workload and give valuable help to patients. In this paper, we targeted this goal and designed an automatic method to detect bruxism from the physiological signals using a novel hybrid classifier. We began with data collection. Then, we performed the analysis of the physiological signals and the estimation of the power spectral density. After that, we designed the novel hybrid classifier to enable the detection of bruxism based on these data. The classification of the subjects into “healthy” or “bruxism” from the electroencephalogram channel (C4-A1) obtained a maximum specificity of 92% and an accuracy of 94%. Besides, the classification of the sleep stages such as the wake (w) stage and rapid eye movement (REM) stage from the electrocardiogram channel (ECG1-ECG2) obtained a maximum specificity of 86% and an accuracy of 95%. The combined bruxism classification and the sleep stages classification from the electroencephalogram channel (C4-P4) obtained a maximum specificity of 90% and an accuracy of 97%. The results show that more accurate bruxism detection is achieved by exploiting the electroencephalogram signal (C4-P4). The present work can be applied for home monitoring systems for bruxism detection.