: Lack of adequate sleep is a major source of many harmful diseases related to heart, brain, psychological changes, high blood pressure, diabetes, weight gain etc. The 40 to 50 % of the world’s population is suffering from poor or inadequate sleep. Insomnia is a sleep disorder in which individual complaint of difficulties in starting/continuing sleep at least four weeks regularly. It is estimated that 70% of the heart diseases are generated during insomnia sleep disorder. The main objective of this study to determine the all work conducted on insomnia detection and to make a database. We used two procedures including network visualization techniques on two databases including PubMed and Web of Science to complete this study. We found 169 and 36 previous publications of insomnia detection in the PubMed and the Web of Science databases, respectively. We analyzed 10 datasets, 2 databases, 21 genes, and 23 publications with 30105 subjects of insomnia detection. This work has revealed the future way and gap so far directed on insomnia detection and has also tried to provide objectives for the future work to be proficient in a scientific and significant manner.

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This study explores the effects of maternal separation as a chronic early life stress (ELS) on pancreatic islets insulin content and secretion, and their potential relationship with the hippocampus insulin content and spatial memory in young adulthood.Male rat offspring were divided into two groups: stress (STR) and non-stress (non-STR) groups. The animals of the STR group were separated from their mothers during postnatal days (PND) 1 to 21. During the weaning time, that is, PND-0 to PND-21, the body weight and length of the pups were measured. Blood samples were collected on PND-1, 21, 29 and 34 and during young adulthood (53±2 days) to determine plasma corticosterone and insulin levels. The young adult animals were also tested for spatial memory. One day after the memory test, the animals were decapitated and their pancreases were removed to measure the islets insulin content and secretion. Finally, the animals’ hippocampi were isolated to determine their insulin content and insulin receptor protein amounts.During the period of weaning, the body weight and length of pups belonging to the STR group were significantly lower as compared to those in the non-STR group. Maternal separation did not change the plasma levels of insulin but increased plasma corticosterone levels from PND-21 to young adulthood and also reduced the islets insulin content but did not affect insulin secretion and the hippocampus insulin content and insulin receptor protein amount. Although, at the end of the memory tests, rats of the STR group reached the escape box at almost the same time and distance and with the same errors as rats of the non-STR group, the distance traveled to reach the escape box showed a steep reduction in the non-STR group as compared to the STR group after the first trial. Moreover, as compared to the STR group, the non-STR group showed an increasing trend for direct strategy to find the escape box. The islets insulin content and secretion, and the plasma insulin concentration were not significantly correlated with the hippocampus insulin content.From the results of the present study, it appears that the main behavioral effect of the maternal separation stress in the spatial memory task was to impair the strategy used by the animals to reach the escape box. This may indicate that maternal separation stress affects brain regions other than the hippocampus. Moreover, due to the reduction of the body weight and length of offspring belonging to the STR group, it should be further considered that both maternal separation and early life malnutrition are directly (and mechanistically) linked to cognitive alterations later in life in ways that are not dependent on peripheral and hippocampal insulin content.

In this work, the feasibility to recycle pure magnesium machining chips is first investigated experimentally with a solid-state recycling technique of friction stir extrusion (FSE). Heat generated from frictions among the stirring chips, die, and mold facilitates the extrusion process. Mechanical tests, optical microscopy (OM), and scanning electron microscopy (SEM) analysis are conducted to evaluate the mechanical and metallurgical properties of extruded wires. Mechanical tests show that almost all recycled specimens can achieve higher strength and elongation than original material of magnesium at room temperature. Due to a refined grain microstructure, good mechanical properties are obtained for samples produced by the rotational speed of 250 rpm and plunge rate of 14 mm/min. A metallo-thermo-mechanical coupled analysis is further conducted to understand the effects of process parameters. The analysis is carried out with a multistep two-dimensional (2D) coupled Eulerian–Lagrangian finite-element (FE) method using abaqus. The material constitutive model considers both work hardening and strain softening. Material grain size evolution is modeled by dynamic recrystallization (DRX) kinetics laws. The deformation process and its consequential microstructural attributes of grain size and microhardness are simulated. Physics principles of the microstructure evolution are discussed based on both experimental and numerical analyses.

Percutaneous coronary angioplasty (PCI) and stent implantation are the most common therapeutic strategies for coronary artery stenosis; however, in-stent restenosis (ISR) is one of its important challenges. Although in some studies, coronary artery disease (CAD) factors are deemed to be the causes of ISR, in some others, the relationship between CAD factors and ISR are not observed. Over the past ten years, there has been no review article on factors affecting the ISR. This article aimed to review the possible factors affecting ISR in patients undergoing PCI. This narrative review study was conducted on PubMed, Web of Science, Scopus, and Google Scholar databases between 1 January 1990 and 30 July 2017. After initial screening of 1728 retrieved articles, 1401 articles were excluded to due irrelevancy to the review; and finally, 39 papers were selected for data collection. Our study results showed that the site and length of implanted stent, hypertension and diabetes are the most probable factors affecting ISR. Further studies are required for evaluation of the effect of other possible risk factors such as genetic sequencing, obesity, chronic infections and hemoglobin A1C levels. [GMJ.2018;7:e961]