The aim of this study was to evaluate the relation between inflammatory markers and the preatherosclerotic marker - flow mediated dilation (FMD). Thirty obese children (10-16 years old) and twenty controls were involved. The plasma inflammatory markers: CRP, fibrinogen, leptin, TNF-a, IL-6 were measured. Ultrasounds were used for FMD measurement, chemiluminescence for monocyte respiratory burst (RB), ELISA for C peptide and spectrophotometry for usual parameters. In the obese children versus the lean ones, the FMD was lower (p[0.001), the plasma values for TNF-a were similar (1.68 pg/mL vs 1.54 pg/mL), while plasma IL-6 was increased (4.01 pg/mL vs. 2.02 pg/mL, p[0.05). These cytokines were negatively correlated with FMD (r=-0.42, p[0.05) and positively with RB (r=50, p[0.05). The FMD was negatively correlated (p[0.05) with the values for diastolic blood pressure (r = -0.47), waist circumference (r = -0.55), uric acid (r = -0.47) and atherosclerotic index (r = -0.37). In conclusion, in the obese children, inflammation, dyslipidaemia, blood pressure and oxidative stress act in a cluster reducing the elasticity of the vessel walls.
Glucocorticosteroids are the mainstay of treatment in many inflammatory and autoimmune disorders. Their administration can be associated with various side effects, similar to those within the metabolic syndrome. The beneficial effects of vitamin E in metabolic syndrome were demonstrated by many studies. Nowadays, vitamin E can be administrated through a new and innovative system delivery, such as polylactic-co-glycolic acid nanoparticles (PLGA-NPs). The aim of this experimental study was to compare the metabolic and haematological parameters after Prednisone administration as a single drug or in combination with vitamin E delivered by PLGA-NPs. Wistar male rats (n=15, age 10-12 months), on standard diet were randomised in three groups, for 6 weeks as: group SC served as a control, group SP was treated with Prednisone (1 mg/kg/day) by oral gavage and group SN received Prednisone (1 mg/kg/day) and vitamin E-charged PLGA nanoparticles (1 mg/kg/day) by oral gavage. In the Prednison treated group versus control, higher levels (p[0.05) were demonstrated for visceral fat weight, glycosylated hemoglobin (HbA1c), cholesterolemia and triglyceridemia. The association of PLGA-NPs charged with vitamin E to Prednisone prevented (p[0.05) hypercholesterolemia and visceral fat development induced by the cortisol intake. In conclusion, polylactic-co-glycolic acid nanoparticles (PLGA-NPs) charged with Vitamin E may demonstrate promising results in decreasing side effects induced by glucocorticosteroids, by reducing the amount of visceral fat and cholesterolemia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.