Vascular Reactivity and Proinflammatory Cytokines in the Obese Children

Popescu, L; Vîrgolici, Bogdana; Stefan, Daciana; Lixandru, Daniela; Olivia, Timnea; Virgolici, Horia; Orăşeanu, Dumitru; Sinescu, Crina; Mohora, Maria

doi:10.37358/rc.17.4.5547

Cited by 7 publications

(9 citation statements)

References 26 publications

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“…The lipids are used as substrates for oxidation, stimulate radical formation and finally contributes to the accumulation of oxidation products in adipose tissue, which may cause in the end thrombosis, endothelial dysfunction and atherosclerosis [18][19][20][21]. Dyslipidemic profile is characterized by increased levels of triglycerides, LDL, 4-hydroxyinonenal, malondialdehyde (MDA), low levels of HDL and antioxidants [21][22][23][24][25].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

Miricescu¹,

Totan²,

Stanescu³

et al. 2019

Mat.Plast.

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The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The purpose of our study was to observe the antioxidants effects of entrapped alfa-tocopherol (vitamin E) and lutein in Poly Lactic-CO-Glycolic acid (PLGA) in Wistar rats that received 3 weeks hypercaloric diet. Hepatic and splenic lysates have been used to detect changes in total antioxidant capacity (TAC) and advanced oxidative protein products (AOPP). The AOPP liver levels were statistically decreased in the case of rats groups that received a daily dose of PLGA-lutein or PLGA-vitamin E versus the control group. The AOPP level was decreased but statistically insignificant in Wistar rats spleen who received a daily dose of PLGA-lutein. At hepatic level, TAC was statistically increased in rats groups that received a daily dose of vitamin E or lutein. An increased statistical level of TAC was observed in the spleen cell lysing in Wistar rats who received the daily dose of PLGA-vitamin E. Entrapment of vitamin E and lutein in PLGA structure has diminished the effects of hypercaloric diet and can be considered a attractive and promising approach to enhance the bioavailability and activity of poorly water soluble compounds.

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Section: Resultsmentioning

confidence: 99%

Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

Miricescu¹,

Totan²,

Stanescu³

et al. 2019

Mat.Plast.

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“…MMPs can contribute to angiogenesis in three ways: enable endothelial cell migration through neighboring tissues by destroying ECM barriers, the second way is that they can promote it by liberating angiogenic factors that were sequestered, and the last but not the least way: they can deny it by generating anti-angiogenic breakdown products. In addition, the balance between MMPs and their inhibitors must be restored during the maturation of newly formed blood vessels to favor basement membrane assembly and endothelial cell differentiation and quiescence [38].…”

Section: Mmps In Vascular Remodelingmentioning

confidence: 99%

“…However, the importance of MMPs in down-modulating angiogenesis is unclear, whereas they are clearly important positive regulators of angiogenesis [38].…”

Section: Mmps In Vascular Remodelingmentioning

confidence: 99%

“…Some MMPs may defy cancer progression, and others may not participate in cancer, but undoubtedly play normal physiologic roles. These possibilities must be considered and the mechanisms underlying the influence of MMPs in cancer must be understood in terms of therapeutic agents in order to optimize their efficacy and minimize their toxicity [38,39]. The proteolytic cleavage of the ECM plays a key role in the malignant development.…”

Section: Mmps In Cancermentioning

confidence: 99%

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The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity

Mirică¹,

Ionescu²,

Mirică³

et al. 2017

Rev. Chim.

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Obesity involves the growth of adipose tissue cells (adipocytes and preadipocytes), as well as microvascular endothelial cells. Matrix metalloproteinases (MMPs) are relevant ezymes for the modulation of extracellular matrix (ECM) and adipocyte and preadipocytes differentiation. They are elevated in obese patients, generating abnormal ECM metabolism.[1]. This article proposes a thorough study of literature with focus on the important roles of matrix metalloproteinases in the pathophysiology of obesity. The article represents a narrative review based on an English-language PubMed research of the medical literature regardind important aspects of the proposed aim. MMP-2 activity was signi�cantly higher than MMP-9, both activities were detectable. MMP-9 was strongly correlated with body weight parameters before surgery, as well as after significant body weight reduction as a result of bariatric surgery. Concerning MMP-2 and MMP-9 they are also involved in the turnover of basement membranes both those of adipose tissue and endothelial. MMP-9 levels were moderately correlated with HDL cholesterol levels. Taken together, the present data suggest that changes in ECM through MMP-mediated degradation might play a critical role in the adipocyte differentiation process. These findings are detected both in clinical trials and in laboratory animal experiments. It is then tempting to speculate that the adipocyte-derived MMPs might represent a new pharmacological target for the inhibition of adipose tissue growth by inhibiting adipose differentiation as well as angiogenic process.

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“…Being multi factorial and complex disease obesity is related with behavioral, endocrine and metabolic changes, leading to multi-system malfunctions. In this sense are well defined the obesity-related implications on endocrine system, nervous and cardiovascular function [5,6].…”

mentioning

confidence: 99%

Evolution of the Thyroid Hormones and Thyreostimulin in Obese Children

Ochiana¹,

Ananie²,

Bădărău³

et al. 2019

Rev. Chim.

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The study objective is the correlation of thyroid function to the weight status in a study group made up of schoolchildren in Galati County. Six of ten overweight children before puberty will became obese during adulthood. PREDATORR study published in May 2014, placed our country in the top among overweight and obesity European incidence, showing a 34.7% prevalence of overweight and 31.9% obesity in subjects in the age group 20-79 years. Unfortunately the study did not offer epidemiological data regarding children population. The data obtained allow the characterization of the thyroid function in relation to weight status in school age children, in a county both in urban and rural area, taking in account that there are fewer studies in rural in this moment. It brings further information on thyroid function and pathology in pediatric obesity in relation to metabolic comorbidities. We identified an increased fT3 and TSH in obese children, sustaining the association between dyslipidemia, thyroid function, anxiety and depression, as long as the data obtained adult are still controversial.

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Vascular Reactivity and Proinflammatory Cytokines in the Obese Children

Cited by 7 publications

References 26 publications

Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

The Important Roles of Matrix Metalloproteinases in the Pathophysiology of Obesity

Evolution of the Thyroid Hormones and Thyreostimulin in Obese Children

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