Significance and Impact of the Study: Lactiplantibacillus plantarum HOM3204 was isolated from homemade pickled cabbage. Lact. plantarum HOM3204 showed excellent probiotic characterization in vitro tests. Lact. plantarum HOM3204 significantly restored the gut microbiota composition by increasing the abundance of Lactobacilli and Bifidobacteria and decreasing Enterococci, and improved antioxidative function by raising the concentrations of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in serum of antibiotic-induced dysbiosis in mice. These results suggest that Lact. plantarum HOM3204 could be a potential probiotic as a functional food ingredient.