Maleoylchloride on cyclocondensation with aromaticacidhydrazides yields 2-aroyl-6hydroxy-3(2H)-pyridazinones (1a-o). Compounds (1a-o) on chlorination with POCI3 followed by the action of hydrazine hydrate affords corresponding 2-aroyl-6-chloro-3(2H)-pyradazinones (2a-o) and 2-aroyl-6-hydrazino-3(2H)-pyradazinones (3a-o). Compounds (1a-o) on reaction with monochloroaceticacid in aq.NaOH furnishes 2-aroyl-6-carboxymethoxy-3(2H)-pyradazinones (4a-o). The constitution of the products (1 to 4) have been elucidated by elemental analyses and spectral data. The products have been assayed for their antimicrobial activities.( 4a · 0 ) R = Aryl 267 Brought to you by |
Synthesis of 5,7-Diarylpyrazolo[1,5-a]pyrimidines via KOH Mediated Tandem Reaction of 1H-Pyrazol-3-amines and Chalcones. -The title process offers operational simplicity, short reaction times, and good functional group tolerance. -(KASWAN, P.; PERICHERLA, K.; PUROHIT, D.; KUMAR*, A.; Tetrahedron Lett. 56 (2015) 3, 549-553, http://dx.
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