ChemInform Abstract: Synthesis of 5,7‐Diarylpyrazolo[1,5‐a]pyrimidines via KOH Mediated Tandem Reaction of 1H‐Pyrazol‐3‐amines and Chalcones.

Abstract

Synthesis of 5,7-Diarylpyrazolo[1,5-a]pyrimidines via KOH Mediated Tandem Reaction of 1H-Pyrazol-3-amines and Chalcones. -The title process offers operational simplicity, short reaction times, and good functional group tolerance. -(KASWAN, P.; PERICHERLA, K.; PUROHIT, D.; KUMAR*, A.; Tetrahedron Lett. 56 (2015) 3, 549-553, http://dx.

An Efficient and Transition Metal-Free Base-Promoted Multi-Component Synthesis of Aza-Fused Polysubstituted Pyrido[2′,3′:3,4]Pyrazolo[1,5-a]Pyrimidine Derivatives

“…[6][7][8][9][10][11][12] Analogues of pyrazolo [1,5-a]pyrimidines were also known for their wide range of biological activities such as anti-microbial, 13 anti-bacterial, 14,15 anti-inflammatory, 16,17 anti-tumor, [18][19][20] anti-trichomonal, 21 and KDR kinase inhibition. [22][23][24][25][26] Recent discoveries in material sciences has proved that pyrazolo [1,5-a]pyrimidines containing nitrogen-fused compounds are useful synthetic intermediates in the dyestuff industry, they also found use as semiconductors, and organic light emitting diodes. [27][28][29][30][31] Due to the such important bioactivities of fused pyrazolo [1,5-a]pyrimidines derivatives, considerable attention has been focused on the development of environmentally-friendly methodologies to synthesize fused pyrazolo [1,5-a]pyrimidines in the main core structure.…”