Compounded 3,4-DAP products are subject to considerable variability in active drug substance content. This variability seems to be principally because of heterogeneous formulated material rather than variation in dosage form weight.

A method has been developed for the estimate of total tissue sodium by direct measurement of radiosodium concentrations in undigested samples. Accuracy is comparable to that of flame photometric estimates on tissue digests; time and cost, about one-quarter as great. The method appears particularly useful for experimental designs requiring multiple tissue sodium measurements.

No abstract

No abstract