Effects of Diet, Salt Intake and Salt-Loading on Tissue Sodium Concentration and Turnover

Green, D. M.; Reynolds, Telfer B.; Girerd, R. J.

doi:10.1152/ajplegacy.1955.181.1.97

Cited by 6 publications

(2 citation statements)

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“…18 " 20 The decrease in serum sodium and increase iu serum potassium which resulted from a diet low in sodium has been noted previously, 19 and requires no additional comment. The experience with reserpine requires some caution in interpretation.…”

Section: Blood Pressure Responses Grollman and Harrisonmentioning

confidence: 69%

Sodium Restriction and Reserpine Administration in Experimental Renal Hypertension

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Tobian

1958

Circulation Research

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An increase of intracellular potassium and sodium content in the wall of the aorta occurs in experimental renal hypertension. The elevated potassium tends to revert toward normal when blood pressure is again lowered with reserpine. The efficacy of rigid restriction of dietary sodium intake in decreasing blood pressure proved quite limited. The development of renal hypertension in the face of rigid sodium restriction further demonstrates that dietary sodium plays no more than an enhancing role in the pathogenesis of renal "ischemic" hypertension. R ESTRICTION of dietary intake of sodium is often but not always of value in severe hypertension in humans, and the mechanism by which it sometimes lowers blood pressure remains obscure. The demonstration that the renal arteries of hypertensive patients contain an increased amount of sodium 1 suggested that the effect of a diet low in sodium might be to reverse this "chemical lesion." In several types of experimental hypertension in the rat, an elevation of both sodium and potassium in the aortic wall has been demonstrated.2 ' s The following studies were undertaken, therefore, to delineate further the relationships between dietary intake of sodium, compositional changes in the aorta, and blood pressure. EXPERIMENT I : EFFECT OF RESTRICTION OF DIETARY SODIUMBecause different types of renal hypertension might respond differently to variations in dietary sodium, two types of renal hypertension were studied simultaneously.

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Section: Blood Pressure Responses Grollman and Harrisonmentioning

confidence: 69%

Sodium Restriction and Reserpine Administration in Experimental Renal Hypertension

Redleaf

Tobian

1958

Circulation Research

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show abstract

“…On the other hand, any radio-sodium that has entered the slowly exchanging part in the bone is not affected by this rapid turnover. Following the elimination of the radio-sodium from the extracellular fluid the specific activity of the bone sodium relative to blood becomes extremely high (Green, Reynolds & Girerd, 1955). The measurements made in rats fed with an increased amount of sodium after a prolonged period of restriction and in the rats treated with intraperitoneal saline injections showed that 22Na had entered a part of the bone that was effectively isolated from the extracellular fluid.…”

Section: Discussionmentioning

confidence: 99%