Excretion of Sodium-Retaining Factor by Cortisone-Treated, Adrenalectomized Hypertensive Patients

Girerd, R. J.; Green, D. M.

doi:10.1530/acta.0.0280001

Cited by 6 publications

(3 citation statements)

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“…Adherence to medication was determined using a validated score based on six questions about the patient's behaviour and actual use of the prescribed treatment. 15 A score of 6 indicates good adherence to prescribed medication, a score of 4-5 poor adherence and a score ≤3 non-adherence. 15 The data on routinely measured biochemical variables (including HbA1c, fasting blood glucose, creatinine, lipids, and urine albumin and creatinine) came from local medical laboratories.…”

Section: Measures At Baselinementioning

confidence: 99%

“…15 A score of 6 indicates good adherence to prescribed medication, a score of 4-5 poor adherence and a score ≤3 non-adherence. 15 The data on routinely measured biochemical variables (including HbA1c, fasting blood glucose, creatinine, lipids, and urine albumin and creatinine) came from local medical laboratories. The eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation, 16 and CKD stages were defined according to the 2012 Kidney Disease Improving Global Outcomes report.…”

Section: Measures At Baselinementioning

confidence: 99%

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The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

Bonnet,

Balkau,

Lambert

et al. 2024

Diabetes Obesity Metabolism

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AimThe risk of cardiorenal events remains high among patients with diabetes and chronic kidney disease (CKD), despite the prescription of recommended treatments. We aimed to determine whether the attainment of a combination of nephroprotection targets at baseline (glycated haemoglobin <7.0%, urinary albumin‐creatinine ratio <300 mg/g, blood pressure <130/80 mmHg, renin‐angiotensin system inhibition) was associated with better cardiorenal outcomes and lower mortality.Materials and MethodsFrom the prospective French CKD‐REIN cohort, we studied 1260 patients with diabetes and CKD stages 3‐4 (estimated glomerular filtration rate: 15‐60 ml/min/1.73 m2); 69% were men, and at inclusion, mean ± SD age: 70 ± 10 years; estimated glomerular filtration rate: 33 ± 11 ml/min/1.73 m2. The median follow‐up was 4.9 years.ResultsIn adjusted Cox regression models, the attainment of two nephroprotection targets was consistently associated with a lower risk of cardiorenal events [hazard ratio 0.70 (95% confidence interval 0.57‐0.85)], incident kidney failure with replacement therapy [0.58 (0.43‐0.77)], four major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke, hospitalization for heart failure) [0.75 (0.57‐0.99)] and all‐cause mortality [0.59 (0.42‐0.82)] when compared with the attainment of zero or one target. For patients with a urinary albumin‐creatinine ratio ≥300 mg/g, those who attained at least two targets had lower hazard ratios for cardiorenal events [0.61 (0.39‐0.96)], four major adverse cardiovascular events [0.53 (0.28‐0.98)] and all‐cause mortality [0.35 (0.17‐0.70)] compared with those who failed to attain any targets.ConclusionsThese findings suggest that the attainment of a combination of nephroprotection targets is associated with better cardiorenal outcomes and a lower mortality rate in people with diabetic kidney disease.

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Section: Measures At Baselinementioning

confidence: 99%

Section: Measures At Baselinementioning

confidence: 99%

The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

Bonnet,

Balkau,

Lambert

et al. 2024

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

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“…The questionnaire included 61 demographic and clinical items including standard of care self-questionnaires such as the Asthma Control Questionnaire (ACQ), 15,16 Asthma Quality of Life Questionnaire (Mini-AQLQ) 16 and compliance evaluation test. 17 The ACQ was historically the first questionnaire specifically developed and validated to measure asthma control. The Mini-AQLQ was based on the AQLQ, which was developed to measure the functional impairments that are most troublesome to adult asthma patients.…”

Section: Questionnairementioning

confidence: 99%

Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study

Guilleminault,

Camus,

Raherison-Semjen

et al. 2023

Ther Adv Respir Dis

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Background: Biological therapies have revolutionized the treatment of severe asthma with type 2 inflammation. Although such treatments are very effective in reducing exacerbation and the dose of oral steroids, little is known about the persistence of symptoms in severe asthma patients treated with biologics. Purpose: We aim to describe asthma control and healthcare consumption of severe asthma patients treated with biologics. Design: The Second Souffle study is a real-life prospective observational study endorsed by the Clinical Research Initiative in Severe Asthma: a Lever for Innovation & Science Network. Methods: Adults with a confirmed diagnosis of severe asthma for at least 12 months’ duration were enrolled in the study. A self-administered questionnaire including the Asthma Control Questionnaire (ACQ), Asthma Quality of Life Questionnaire (AQLQ) and a compliance evaluation test was given to the patients. Healthcare consumption within 12 months prior to enrolment was documented. In patients receiving biologics, doctors indicated whether the patients were biologic responders or non-responders. Results: The characteristics of 431 patients with severe asthma were analysed. Among them, 409 patients (94.9%) presented asthma with type 2 inflammation (T2 high) profile, and 297 (72.6%) patients with a T2 high phenotype were treated with a biologic. Physicians estimated that 88.2% of patients receiving biologics were responders. However, asthma control was only achieved in 25.3% of those patients (ACQ > 0.75). A high proportion of patients (77.8%) identified as responders to biologics were not controlled according to the ACQ score. About 50% of patients continue to use oral corticosteroids either daily (25.2%) or more than three times a year for at least three consecutive days (25.6%). Gastro-oesophageal Reflux Disease (GERD) and Obstructive Sleep Apnoea syndrome (OSA) were identified as independent factors associated with uncontrolled asthma. Conclusion: Although a high proportion of severe asthma patients respond to biologics, only 25.3% have controlled asthma. GERD and OSA are independent factors of uncontrolled asthma.

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Der Einflu� hoher Aldosteron-Gaben auf die Elektrolyt-Ausscheidung bei gesunden Schwangeren

Stark

Derra

1965

Arch. Gynak.

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Excretion of Sodium-Retaining Factor by Cortisone-Treated, Adrenalectomized Hypertensive Patients

Cited by 6 publications

References 0 publications

The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study

Improvement in severe asthma patients receiving biologics and factors associated with persistent insufficient control: a real-life national study

Der Einflu� hoher Aldosteron-Gaben auf die Elektrolyt-Ausscheidung bei gesunden Schwangeren

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