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MBoRTSH 431 distributions of symptoms at the first examination were very similar for the two groups.The results for the patients who reported on each of the three days are shown in Table II. On each day the proportion recovering was slightly smaller in the treated than in the control series, but none of the differences is statistically significant. The experience of the patients with incomplete records is shown in Table III. In this group the controls also showed a statistically insignificant advantage over the treated. No direct or indirect questions were asked concerning possible side-effects. The number of patients who had conditions which they attributed to the treatment was too small for detailed analysis, for only 14 in the treated group and 13 in the control group complained that the tablets had any adverse effects. Most of the symptoms described could in fact have been symptoms of the cold. ConclusionA large-scale trial of antistin failed to show that this drug had any effect on the course of the common cold.We are greatly indebted to the managements and medical staffs of the centres where the trials were carried out, and we should like to thank the following people in particular for their co-operation and assistance:

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