Gingival hyperplasia associated with cyclosporin A. A report of two cases

Cyclosporin‐Induced Gingival Overgrowth at the Newly Formed Edentulous Ridge in Rats: A Morphological and Histometric Evaluation

“…[9][10][11][12][13][14] Clinically, the gingival overgrowth starts at interproximal papillae, more frequently in anterior facial areas, and partially covers the crowns. [9][10][11][12][13][14] Since the overgrowth seldom occurs at sites distant from teeth, the periodontal ligament has been considered significant for the overgrowth development. 10,[14][15] However, a case of severe mucosal hyperplasia in the edentulous maxilla associated with CsA therapy has been reported.…”

“…[9][10][11][12][13][14] Since the overgrowth seldom occurs at sites distant from teeth, the periodontal ligament has been considered significant for the overgrowth development. 10,[14][15] However, a case of severe mucosal hyperplasia in the edentulous maxilla associated with CsA therapy has been reported. 16 Therefore, the aim of this study was to examine whether CsA therapy can induce gingival enlargement on a newly formed edentulous ridge in the rat, and to further evaluate the hypothesis that periodontal ligament is an essential component in CsAinduced gingival overgrowth formation.…”

The Effect of Cyclosporin A on Alveolar Bone in Rats Subjected to Experimental Periodontal Disease

“…CsA has been broadly used in organ transplantation because of its selectively suppressive action on specific T lymphocytes, and blocking synthesis and secretion of certain lymphokines (Calne et al, 1979;Bunjes et al, 1981). CsA has also been used for the treatment of type 2 diabetes, rheumatoid arthritis, psoriasis, multiple sclerosis, malaria, sarcoidosis, and several other immune diseases (Adams and Davies, 1984). The main side effects of CsA include nephrotoxicity, hepatic dysfunction, neurological disturbances, hypertension, and gingival overgrowth (Keown and Stiller, 1987;Seymour et al, 2000).…”

Prevalence and Risk of Gingival Enlargement in Patients Treated With Nifedipine

“…Chronic inflammation due to dental plaque frequently causes gingival overgrowth. [1][2][3][4] Drugs associated with gingival enlargement include antiepileptics such as phenytoin; 5-7 cyclosporin A; [8][9][10][11][12][13][14][15][16] and calcium channel blockers, such as dihydropyridine, [17][18][19][20][21][22] verapamil, [23][24][25][26][27] and diltiazem. [27][28][29][30][31][32] The clinical and pathologic features in drug-induced gingival overgrowth are independent of the drug administered, which suggests a common pathway of induction.…”