The process of drug release out of dosage forms made of the drug dispersed in a lipidic Gelucire is considered. The process is based on the following three ideas: first, the liquid dissolves the drug in contact with it and occupies its previous place; second, the drug diffuses out of the dosage form through the liquid located in it, and third, the diffusivity of the drug varies with the concentration of the liquid in an exponential way. These assumptions are drawn from the following experimental observations: no change in dimension of the dosage form takes place; the amount of drug release after a long time is greater than that evaluated with a constant diffusivity. Good agreement is obtained between the kinetics of drug release obtained either by calculation or from experiments using in vitro tests.
It is sometimes desirable to dissolve a drag in the intestine rather than in the stomach, even if the drug is soluble in the gastric liquid and only slightly soluble in the intestine. This difficult problem can be resolved by using dosage forms where the drug is dispersed into a mixture of two typical polymers. In this study, the two polymers used are Gelucire and Sumikagel.In gastric liquid, Sumikagel swells moderately while Gelucire is stable. In intestinal liquid, Sumikagel swells to such a great extent that the Gelucire is dispersed into very small droplets, which enable it to dissolve at a higher rate.
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