Kinetics of in vitro release of sodium salicylate dispersed in Gelucire

Bidah, D.; Vergnaud, J.M.

doi:10.1016/0378-5173(90)90198-d

Cited by 23 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Korsmeyer-Peppas equation is used to analyze the release of pharmaceutical polymeric dosage forms, when the release mechanism is not well known or when more than one type of release phenomena could be involved[ 28 ]. The erosion equation describes the drug release from slabs, spheres and infinite cylinders displaying heterogeneous erosion[ 29 ]. The applicability of all of these equations was tested in this work.…”

Section: Resultsmentioning

confidence: 99%

Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets

Keny¹,

Mankame²,

Lourenco³

2009

Indian J Pharm Sci

View full text Add to dashboard Cite

The present study was aimed to develop once daily extended release matrix tablets of minocycline hydrochloride, using hydroxypropylmethylcellulose either alone or in combination with ethyl cellulose as the matrix material in different proportions. The formulated tablets were also compared with a marketed product. The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h. Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX), the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix. Mathematical treatment of the in vitro drug release data suggests that, all the formulations best fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and erosion of tablet surface, which was reflected from Higuchi's model and Erosion plot.

show abstract

Section: Resultsmentioning

confidence: 99%

Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets

Keny¹,

Mankame²,

Lourenco³

2009

Indian J Pharm Sci

View full text Add to dashboard Cite

show abstract

“…The dosage form was assumed to be spherical in shape, with the release controlled by radial diffusion with a diffusivity which does not depend on the drug concentration and the p H of the liquid. The coefficient of mass transfer on the surface of the dosage form is very high (Bidah & Vergnaud 1990).…”

Section: Mathematical Treatmentmentioning

confidence: 99%

“…Oral dosage forms are most suitable for the patient, make out-patient treatment possible, and avoid the cost and inconvenience associated with intravenous administration. Oral dosage forms are usually tested by using the in-vitro dissolution test, which is the tool for characterizing the biopharmaceutical quality of the drug at various stages of the development and thus evaluating the possible risks (Siewert 1993), and also for determining the kinetics of drug release under given conditions of p H and stirring (Bidah & Vergnaud 1990). Various results have thus been obtained, and a few of them are summarized.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prediction of In-vivo Blood Level with Controlled-release Dosage Forms. Effect of the Gastrointestinal Tract Time

Ouriemchi

Vergnaud

1996

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

The process of in-vivo drug transfer is very complex in the case of oral dosage forms with controlled release. A numerical model taking all the known facts into account, including the release of the drug controlled by diffusion through the dosage form along the gastrointestinal tract, the kinetics of absorption in the blood compartment and the kinetics of elimination was constructed. Various parameters intervene in an important manner for a given drug: the size of the dosage form which is associated with the rate of release of the drug, and the dose frequency in multidosing. Some emphasis is placed upon the gastrointestinal tract time which appears to be the main and first parameter to be considered in preparing a dosage form.

show abstract

“…To achieve maximum therapeutic effect with a low risk of adverse effects, sustained released preparations are preferred. [ 4 6 ] Moreover the drug is unstable in gastric pH. Coating with pH-dependent polymers approach is one of the simplest and easiest approaches available for intestinal drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of sustained release enteric-coated pellets of budesonide for intestinal delivery

Raval

Ramani

Sheth

2013

Int J Pharma Investig

View full text Add to dashboard Cite

Introduction:The aim of present work was to develop intestinal-targeted pellets of Budesonide, a potent glucocorticoid, used for the treatment of ulcerative colitis and Crohn's disease by extrusion and spheronization method. Current available oral formulations of Budesonide have low efficacy because of the premature drug release in the upper part of the gastrointestinal tract. In this study, a pH-controlled intestinal-targeted pellet of budesonide was established using 32 full factorial design by giving an enteric coating with Eudragit S100.Materials and Methods:Budesonide-sustained release pellets were prepared by extruder and spheronization technique using a combination of water-soluble and permeable polymers by applying 32 full factorial design. The pellets were coated by spray coating technique using Eudragit S100 as an enteric polymer. The pellets were characterized for its flowability, sphericity, friability, and in vitro drug release. Release behaviour was studied in different pH media. The release profile was studied for the mechanism of drug release.Result:The optimized formulation showed negligible drug release in the stomach followed by release for 12 h in the intestinal pH. Differential scanning calorimetry and Fourier Transform Infrared Spectroscopy studies indicated no interaction between drug and polymer. Scanning Electron Microscopy image of coated pellets suggested a uniform and smooth coat over the surface of pellets. Accelerated stability studies showed a stable nature of drug in the formulation. All evaluation parameter showed that pellets were good in spherocity and flowability.Conclusion:Sustained release pellets of Budesonide could be prepared by extrusion and spheronization which released the drug in intestinal pH for an intestine to treat inflammatory bowel disease. A ratio of polymer combination could be decided using a full factorial design.

show abstract

Kinetics of in vitro release of sodium salicylate dispersed in Gelucire

Cited by 23 publications

References 13 publications

Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets

Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets

Prediction of In-vivo Blood Level with Controlled-release Dosage Forms. Effect of the Gastrointestinal Tract Time

Formulation and evaluation of sustained release enteric-coated pellets of budesonide for intestinal delivery

Contact Info

Product

Resources

About