Dosage Form for Controlled Delivery to the Intestine of a Drug Soluble in Gastric Liquid and Poorly Soluble in Intestinal Liquid

Abstract

It is sometimes desirable to dissolve a drag in the intestine rather than in the stomach, even if the drug is soluble in the gastric liquid and only slightly soluble in the intestine. This difficult problem can be resolved by using dosage forms where the drug is dispersed into a mixture of two typical polymers. In this study, the two polymers used are Gelucire and Sumikagel.In gastric liquid, Sumikagel swells moderately while Gelucire is stable. In intestinal liquid, Sumikagel swells to such a great extent that the Gelucire is dispersed into very small droplets, which enable it to dissolve at a higher rate.