Abstract:It is sometimes desirable to dissolve a drag in the intestine rather than in the stomach, even if the drug is soluble in the gastric liquid and only slightly soluble in the intestine. This difficult problem can be resolved by using dosage forms where the drug is dispersed into a mixture of two typical polymers. In this study, the two polymers used are Gelucire and Sumikagel.In gastric liquid, Sumikagel swells moderately while Gelucire is stable. In intestinal liquid, Sumikagel swells to such a great extent tha… Show more
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