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What is known on the subject?• Irritability is a transdiagnostic psychiatric symptom among different mental health diagnoses, such as depression, anxiety, personality and substance abuse disorders.• The findings have implications for symptom science, one focus of nursing research that evaluates symptom experiences and their impact on quality of life and functioning.Irritability is consistent with this framework as it has disabling effects on educational, financial and social functioning, as well as vulnerability to psychiatric disorders and healthrelated quality of life.

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