Progressive macular hypomelanosis (PMH) is a condition of unknown etiology characterized by asymptomatic, hypopigmented macules located predominantly on the trunk. We recorded 12 adolescents with PMH over a 6-month period. Ten were female, and the mean age was 16.6 years. The average time from the patients first noticing pigment change to diagnosis was 15 months. PMH is probably an underdiagnosed condition.

Background Sensitization to acrylates is a concern in the occupational/environmental dermatology field. Objective To describe an occupational allergic contact dermatitis (ACD) outbreak from a smartphone screen protector glue. Methods Thirteen affected workers of a chain store selling phone screen protectors were investigated in five Spanish dermatology departments. The glue datasheet and label were assessed. A chemical analysis of the glue was performed. Based on this, some patients underwent additional testing. Results All patients (all female, mean age: 25) had severe fingertip dermatitis. The datasheet/label indicated that the glue contained isobornyl acrylate (IBOA), a “photoinitiator” and polyurethane oligomer. The company informed us that the ingredients were polyurethane acrylate, “methacrylate” (unspecified), acrylic acid, hydroxyethyl methacrylate, propylmethoxy siloxane, and photoinitiator 184. Isobornyl acrylate (or IBOA) and N,N‐dimethylacrylamide (DMAA) were patch tested in eight and two cases, respectively, with negative results. A chemical analysis revealed 4‐acryloylmorpholine (ACMO); isobornyl methacrylate (IBMA), and lauryl acrylate in one glue sample. Seven patients were patch tested with dilutions of the identified substances and six of seven were positive for ACMO 0.5% pet. Conclusion An outbreak of occupational ACD, likely from ACMO in a glue is described. Further investigations are needed to corroborate the role played by each compound identified in the chemical analyses.

Figure 1: (a) Halo CMN on the inner aspect of the right knee when the patient was 8 years old. (b) Follow-up at the age of 10 years. Partial regression of the CMN is observed, as well as patchy areas of repigmentation. (c and d) Substantial repigmentation both halo CMN and vitiligo when the patient was 13 years old d c b a [Downloaded free from http://www.ijdvl.com on Tuesday, January 21, 2014, IP: 202.164.45.14] || Click here to download free Android application for this journal Letters to the Editor

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166 RESUMENEl carcinoma basocelular es el tipo más común de cáncer cutáneo y la neoplasia más frecuente en el ser humano. Este tumor maligno es localmente infiltrante, agresivo y destructivo, pero su capacidad para metastatizar es muy limitada. Existen diferentes tipos: nodular, ulcerativo, pigmentado, esclerosante y superficial. Presentamos el caso de un paciente con carcinoma basocelular pigmentado en el que fue necesario hacer un diagnóstico diferencial con otras patologías como el melanoma maligno, el nevus azul y la queratosis seborreica, en las cuales el manejo y pronóstico del paciente son diferentes.Palabras Clave: Carcinoma Basocelular Pigmentado. Queratosis Seborreica. Melanoma Maligno. Nevus. ABSTRACT Differential diagnosis of pigmented basal cell carcinomaBasal cell carcinoma (BCC) is the most common cutaneous cancer in humans. BCC is locally invasive, aggressive, and destructive but slow in growing, and there is very limited (literally no) tendency to metastasize. Clinically, there are different types: nodular, ulcerating, pigmented, sclerosing, and superficial. We report a pigmented basal cell carcinoma case, which required differential diagnosis from other pathologies such as superficial melanoma, seborrheic keratosis and blue nevus, in which management and prognosis are different. Key words:Basal Cell Carcinoma, pigmented. Keratosis, Seborrheic . Malignant Melanoma. Nevus. Diagnóstico diferencial del carcinoma basocelular pigmentadoFlor Liliana Urrego-Rivera a y Cristina Faura-Berruga b . INTRODUCCIÓNLos problemas dermatológicos son frecuentes en Atención Primaria y se estiman en un 10 %. Por su importancia destacan los tumores dermatológicos y, entre ellos, el carcinoma basocelular, que es el tumor más frecuente en la piel 1 . El carcinoma basocelular es una neoplasia epitelial de malignidad limitada por un crecimiento lento y excepcional capacidad para dar metásta-sis a distancia. Se origina a partir de células indiferenciadas y pluripotentes de la capa basal epidémica. En su origen intervienen factores extrínsecos (factores medioambientales como la fotoexposición) e intrínsecos (genéticos o factores del huésped como la inmunodepresión). La radiación ultravioleta acumulada juega un papel etiopatogénico fundamental 2

RESUMENEl carcinoma basocelular es la neoplasia maligna más frecuente en el ser humano. Se caracteriza por ser localmente invasivo y de crecimiento lento. Presentamos el caso de un paciente con un carcinoma basocelular avanzado, que le causó una marcada destrucción de la región nasal y que por ello no fue susceptible de tratamiento quirúrgico o radioterapia. Para este tipo de pacientes se propone una nueva terapia innovadora, el Vismodegib, una molécula que inhibe la proliferación tumoral y que ha supuesto un gran avance en el manejo de estos pacientes.Palabras clave: Carcinoma basocelular. Destrucción cutánea. Vismodegib. Vía de señalización Hedgehog. ABSTRACT A highly destructive tumourThe basal-cell carcinoma is the most frequent cancer in human beings. It is characterized by being locally invasive and slow-growing. We present the case of a patient with basal cell carcinoma which caused a marked destruction of the nasal region, for which reason he could not be treated surgically or with radiotherapy. For this type of patient, a new innovative therapy is proposed: Vismodegib, a molecule which inhibits the spreading of the tumour and which has signified a great advance in the management of these patients.

Presentamos el caso clínico de un paciente con calcinosis cutis distrofica en glúteo, una patología infrecuente e infra-diagnosticada por la falta de sospecha clínica. Es de vital importancia que aquellos pacientes que presenten calcificaciones cutáneas se les realicen una detallada anamnesis y un estudio analítico con función renal, metabolismo del calcio y fósforo y autoinmunidad para descartar la existencia de patología subyacente como las enfermedades autoinmunes o renales.  

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