In the present work, gold electrodes were modified using a redox-active layer based on dipyrromethene complexes with Cu(II) or Co(II) and a dipodal anion receptor functionalized with dipyrromethene. These modified gold electrodes were then applied for the electrochemical detection of anions (Cl, SO, and Br) in a highly diluted water solution (in the picomolar range). The results showed that both systems, incorporating Cu(II) as well as Co(II) redox centers, exhibited highest sensitivity toward Cl. The selectivity sequence found for both systems was Cl > SO > Br. The high selectivity of Cl anions can be attributed to the higher binding constant of Cl with the anion receptor and the stronger electronic effect between the central metal and anion in the complex. The detection limit for the determination of Cl was found at the 1.0 pM level for both sensing systems. The electrodes based on Co(II) redox centers displayed better selectivity toward Cl anion detection than those based on Cu(II) centers which can be attributed to the stronger electronic interaction between the receptor-target anion complex and the Co(II)/Co(III) redox centers in comparison to the Cu(II)/Cu(I) system. Applicability of gold electrodes modified with DPM-Co(II)-DPM-AR for the electrochemical determination of Cl anions was demonstrated using the artificial matrix mimicking human serum.

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In this paper the preparation and electrochemical characterization of an immunosensor for Chagas disease is described. The results obtained indicating the possibility of modification of ITO surface by formation of an LbL film constructed by the intercalation of PVS as polyanion and AgNP-SiPy + as polycation. The LbL films were then modified by the incorporation of Chagas ATG on theirs surface. These modified LbL films showed a pronounced impedance change when in the presence of the Chagas ATB indicating that this kind of film could be used in a device for diagnosis of Chagas disease.