Electrochemical Immunosensor for Diagnostic of Parasitical Human Diseases

Erdmann, Cristiane Andreia; Inaba, Juliana; Viana, Adriano Golçalves; Pessôa, Christiana Andrade; Wohnrath, Karen; Garcia, Jarem Raul

doi:10.1149/05012.0393ecst

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…A hybrid impedimetric immunosensors was fabricated by modifying the ITO working electrode with layer by layer film addition of silsequioxane 3-n propylpyridinium chloride with poly vinyl sulphate [32]. Santos et al developed an impedimetric biosensor for qualitative diagnosis of trypanosomiasis.…”

Section: Trypanosomamentioning

confidence: 99%

Novel Electrochemical Biosensing for Detection of Neglected Tropical Parasites of Animal Origin: Recent Advances

et al. 2022

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Parasitic diseases are among neglected disease of human and animals, especially in tropical and sub tropical regions. In the era of artificial intelligence, the novel biosensing diagnostic platform is needed for an early control measure implementation. This goal can be successfully achieved by onsite application of electrochemical biosensors. They are being developed towards point of care diagnostics; however commercial availability is scanty. The recent developments during last one decade in terms of the electrode surface modification for rapid diagnosis of important emerging/re-emerging parasites is presented. The information would help future improvement in the electrochemical biosensing of parasites.

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Section: Trypanosomamentioning

confidence: 99%

Novel Electrochemical Biosensing for Detection of Neglected Tropical Parasites of Animal Origin: Recent Advances

et al. 2022

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“…Various strategies for diagnosis of Chagas disease and trypanosomiasis using electrochemical biosensors have been reported . Diniz et al .…”

Section: Tropical Diseasesmentioning

confidence: 99%

“…A hybrid AgNPs‐SiPy + composite prepared from silsesquioxane 3‐n‐propylpyridinium chloride was intercalated with poly(vinylsulfate) for the fabrication of label‐by‐label films and further modification of an ITO electrode. An immunosensor for anti‐ T.cruzi was developed by immobilization the antigen and EIS measurement of antibody interaction . Qualitative diagnosis of Chagas’ disease for verifying the presence or the absence of T cruzi using a simple configuration was also proposed by Santos et al .…”

Section: Tropical Diseasesmentioning

confidence: 99%

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

2017

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Rapid and reliable diagnosis of viral infections and tropical diseases and timely initiation of appropriate treatment are essential for their successful clinical management. This Review summarizes some basic concepts regarding the main viral infection and tropical diseases to which society is facing today and the conventional methods available for their detection. The tremendous potential offered by electrochemical affinity biosensors to address this important challenge, meeting the required demands for viral infections and tropical diseases diagnosis, is clearly stated by discussing challenges, opportunities, implementation, and application of selected examples focused on the determination of specific biomarkers of different molecular (genetic, regulatory, and functional) levels. The highlighted approaches demonstrate the use of a plethora of specific receptors and assay formats and a great diversity of attractive electrochemical approaches in this rapidly advancing and highly interesting field.

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“…Due to these properties, the SiPy + Cl − has been used as stabilizer on the synthesis and incorporation of metallic nanoparticles, MNp-Sipy + Cl − (M = Pt, Ag and Au). [32][33][34][35] These nanocomposites were obtained by reduction in situ of metal salt solutions with nanoparticles sizes around 6-10 nm. For this reason, this ionic hybrid consists as an interesting material for the construction of LbL films.…”

mentioning

confidence: 99%

Development of an Electrochemical Sensor Based on LbL Films of Pt Nanoparticles and Humic Acid

Santos

Wrobel

Santos

et al. 2016

J. Electrochem. Soc.

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We report the first attempt to use a naturally occurring biopolymer, such as humic acid (HA), as modifiers to prepare a new organic-inorganic composite film with the 3-n-propylpyridiniumsilsesquioxane chloride Pt nanoparticles (Pt-SiPy+Cl−). By using layer-by-layer (LbL) technique, we have constructed multilayered films, (HA/Pt-SiPy+Cl−)n and (Pt-SiPy+Cl−/HA)n, with adjustable thickness due to negatively charged macromolecule HA, which assists the electrostatic interaction with the positively charged of the Pt-SiPy+Cl− nanohybrid. The combination of these partially charged polyelectrolytes in the LbL film was explored by spectroscopic and electrochemical techniques. The formation of the film (HA/Pt-SiPy+Cl−)n is more efficient, since the presence of the macromolecule in the inner layer provides a greater number of anchoring sites for the hybrid, ensuring a more linear and uniform growth of the LbL films. This film also presented a better electroanalytical response for oxidation of 17α-ethynylestradiol, EE2, indicating that the Pt nanoparticles strongly influences the electrochemical oxidation of estrogen. The analytical curve for EE2 was linear in the concentration range of 1.37 to 21.4 μmol L−1 (R = 0.998), with a detection limit of 1.10 μmol L−1 and quantification limit of 3.68 μmol L−1. The obtained results showed that the synergism between HA and Pt-SiPy+Cl− improves the electroactive properties of the sensor.

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Electrochemical Immunosensor for Diagnostic of Parasitical Human Diseases

Cited by 5 publications

References 8 publications

Novel Electrochemical Biosensing for Detection of Neglected Tropical Parasites of Animal Origin: Recent Advances

Novel Electrochemical Biosensing for Detection of Neglected Tropical Parasites of Animal Origin: Recent Advances

Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases

Development of an Electrochemical Sensor Based on LbL Films of Pt Nanoparticles and Humic Acid

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