In 2017 leptospirosis cases occur in new areas in Bantul where cases have never been previously reported. Cases still occur in 2018 with an interval of two months after the first case. Preventive and curative efforts in the context of controlling cases have been carried out by the local health office, in addition to these control efforts, it is also necessary to know the presence of Leptospira in rats and water bodies in the area as well as the history of patients transmission. This study was conducted to provide epidemiological data, especially the status of Leptospira in rats as reservoir animal and water bodies as well as a history of patient activity as basic data for leptospirosis control in Gilangharjo Village. This cross-sectional study was conducted at the case location in RT 03 Jodog, Gilangharjo Village, Pandak District, Bantul Regency, which was conducted in April 2018. Leptospira infection status was carried out on rats and water bodies by molecular examination, while the history of transmission based on interviews with patients and the result of the examination of Leptospira status. Rat species caught were dominated by R.tanezumi, R. norvegicus and B. indica. Positive rat infected with Leptospira were found in B. indica while in water bodies Leptospira contamination was not found. Infected rat can be a source of transmission for humans and other animals. Most of the patient's activities were carried out in the fields and at home, all of the patients had wounds that were not treated, and had a history of contact with rats that might transmit Leptospira to humans.
Reports on the rodenticide effect of papain papaya to control rats and mice is scarce. The aim of this study was to determine pathological changes in albino mice internal organs (gaster, kidney, liver and intestine) associated with toxicity effect of papain papaya (Carica papaya L.). Seventy-eight adult BALB/c mice of both sexes were divided into 5 groups: 1 control group and 4 treatment groups that were given papain feeding block. Feed intake and mortalities have been monitored in previous study. At the end of the experimental period, tissues of mice were harvested for necropsy and histopathological examination. The abnormality of post mortem examination were hepatomegaly, gastro-intestinal bleeding. Dark discoloration was founded in liver and gaster. Histopathological changes founded in all treatment albino mice were necrosis in gaster, kidney, liver and intestine. Cloudy swelling occurred in liver and dilatation in kidney. Fatty degeneration occured in gaster, liver and intestine. In addition, the kidney and liver were congested. Feed intake of 16 to 32% papain natural rodenticide gave effect to the organs of studied mice, i.e gaster, kidney, liver and intestine.Reports on the rodenticide effect of papain papaya to control rats and mice is scarce. The aim of this study was to determine pathological changes in albino mice internal organs (gaster, kidney, liver and intestine) associated with toxicity effect of papain papaya (Carica papaya L.). Seventy-eight adult BALB/c mice of both sexes were divided into 5 groups: 1 control group and 4 treatment groups that were given papain feeding block. Feed intake and mortalities have been monitored in previous study. At the end of the experimental period, tissues of mice were harvested for necropsy and histopathological examination. The abnormality of post mortem examination were hepatomegaly, gastro-intestinal bleeding. Dark discoloration was founded in liver and gaster. Histopathological changes founded in all treatment albino mice were necrosis in gaster, kidney, liver and intestine. Cloudy swelling occurred in liver and dilatation in kidney. Fatty degeneration occured in gaster, liver and intestine. In addition, the kidney and liver were congested. Feed intake of 16 to 32% papain natural rodenticide gave effect to the organs of studied mice, i.e gaster, kidney, liver and intestine.
April 2019, the Jeneponto District Health Office be up against outbreak of the acute fever of unknown origin in Garonggong, Tuju Village, West Bangkala District, there were 70 patients with three deaths. South Sulawesi Provincial Health Service investigation found that 27 patients had fever accompanied by nausea, vomiting and headaches since the end of March 2019. Patients also felt pain in the muscles and joints so that there was a suspicion of Leptospira and or Rickettsia infection in the area. Banjarnegara Health Research and Development Unit conducted an epidemiological investigation by examining blood and kidney samples in reservoir animals in the area. Rat capturing was carried out for 2 nights to test Leptospira and Rickettsia content with PCR Methods. A total of 20 rats were caught and PCR test found one individual rat of Rattus tanezumi species positively infected by the bacteria Leptospira sp. Rickettsia examination shows that Xenopxylla cheopis fleas infested R. tanezumi positively infected with Ricketsia sp. We conclude that Garonggong, Tuju Village, West Bangkala Subdistrict, Jeneponto Regency, South Sulawesi has the potential for rat-borne disease transmission, particularly Leptospirosis and Rickettsiosis.
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