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Clinical experience with 57 transfusions of platelet concentrates in 28 patients with thrombocytopenic purpura is reviewed. These concentrates were prepared from normal blood and were given to control active bleeding or to assist hemostasis at surgery. Their use usually was followed by a beneficial effect, which generally lasted from one to several days. Platelet transfusions were most useful in cases of idiopathic thrombocytopenic purpura as a prophylactic measure prior to splenectomy and as supportive therapy in cases of thrombocytopenia secondary to severe but transient depression of the bone marrow.

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