The merging of Virchows Archiv A and B in 1994

Berry, Colin; Dietel, Manfred; Gould, Victor E.; Klöppel, Günter; Pfeifer, U

doi:10.1007/bf01614763

Cited by 1 publication

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“…TGF-β is the key cytokine of fibrosis in most tissues and closely related to the development of fibrosis and the synthesis of ECM (Dong et al, 2016). TGF-β exhibits crucial effects on the regulation of fibrosis and wound healing, which directly or indirectly promotes fibrosis, including the migration and activation of ECM-producing cells and synthesis of ECM proteins (Levine et al, 1993). Moreover, many cytokines regulate ECM degradation by affecting the expression of MMPs and TIMPs (Mäkitalo et al, 2009;Piechota-Polanczyk et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Thalidomide Prevented and Ameliorated Pathogenesis of Crohn’s Disease in Mice via Regulation of Inflammatory Response and Fibrosis

Chen

Luo

et al. 2019

Front. Pharmacol.

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Crohn's disease (CD) is a chronic, relapsing form of inflammatory bowel disease, seriously threatening human health. Thalidomide has been used for the treatment of CD. However, the effects and the possible mechanisms of thalidomide on CD are still unclear. Herein, our study demonstrated that thalidomide protected colon mucosa against trinitrobenzene-sulfonic acid (TNBS)-induced injury, diminished inflammatory infiltration and levels of IFN-γ, IGF-1, IL-6, IL-17, TNF-α, while increased the levels of IL-10 and TGF-γ. Moreover, it reversed the intestinal fibrosis and inhibited the accumulated infiltration, down-regulated the expression of col1a2, col3a2, MMP-3, MMP-9, MMP-1, TGF-γ, α-SMA, but up-regulated the expression of TIMP-1 and Vimentin. Although it could be observed that the effect of thalidomide administration in modeling was better than after modeling, there was no statistical difference between the two groups. The present study provided evidence that the therapeutic effect of thalidomide alleviated the inflammatory response and damage of colon tissue, mainly by restoring the imbalance of TH17/Treg cells and inhibiting intestinal fibrosis in TNBS-induced mice colitis.

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