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A Obesidade é um fator de risco para doenças cardiovasculares e a sua prevalência cresce a cada ano atingindo mais de 2 bilhões de adultos no mundo. As principais recomendações para perda de gordura concentram-se em exercícios de estados estacionários de intensidades moderadas. Entretanto, essas diretrizes não conseguem ser atendidas pela maior parte da população adulta. Sendo assim, novas modalidades ou intensidades de exercícios vem sendo propostas na tentativa de promover perdas mais significativas da gordura corporal. Foi realizado uma revisão sistemática com meta-análise com o objetivo de comparar os efeitos do treinamento intervalado de alta intensidade (HIIT) e do treinamento contínuo nos desfechos: massa corporal total, percentual de gordura, índice de massa corporal e circunferência de cintura de indivíduos com sobrepeso e/ou obesidade. As buscas foram realizadas nas bases de dados Pubmed, Science Direct, PEDro, Scielo e Cochrane Library. A análise foi restrita a ensaios clínicos randomizados em adultos com 18 anos de idade ou mais e com excesso de peso corporal. As meta-análises foram conduzidas utilizando o software Review Manager para modelos de efeitos aleatórios com o método do inverso da variância para os dados contínuos, os dados foram apresentados por diferença da média e IC95%. Quatorze estudos foram incluídos para a análise meta-analítica, houve redução significativa para o grupo CONT para circunferência de cintura (1,19 cm; IC95%: 0,34–2,04; p= 0,006; I2= 0%). Em conclusão, o HIIT não se mostrou melhor estatisticamente em relação ao CONT para alterar os marcadores da composição corporal.

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Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular drugs in the world for treating pain and inflammation. Although the long-term use of NSAIDs is associated with adverse renal, cardiovascular, hepatic, and other effects, it has also been suggested that may cause impairing neuromuscular adaptations promoted by exercise. Objective: The objective of this systematic review was to compare the effects of NSAIDs use in neuromuscular adaptations, such as hypertrophy and muscle strength in middle-aged and elderly practitioners of resistance training. Methods: The databases included Bireme, Pubmed e Science Direct. Meta-analyses were conducted using the robust variance estimation of correlated effects with small-sample adjustments. Results: Six studies were included for meta-analytical analysis. No statistical differences were found for hypertrophy (ES: 0.000531 ± 0.0424, 95%CI: -0.123 – 0.124; P = 0.991) and muscle strength (ES: 0.323 ± 0.213, 95% CI: -0.417 – 1.06; P = 0.258). Conclusion: The findings of this review do not support the hypothesis that the use of NSAIDs combined with resistance exercise negatively influences the hypertrophy and muscle strength.Keywords: non-steroidal anti-inflammatory agents, resistance training, hypertrophy, muscle strength, aged.

After the discovery of the effects of testosterone on muscle strength and hypertrophy, a synthetic formula of this hormone was developed in the late 1930s and came to be called androgenic-anabolic steroids (AAS). 1 These drugs have been used legally by particular individuals, such as the elderly, patients with acquired immunodeficiency syndrome, hypogonadism, anemia that accompanies renal failure, bone marrow failure, endometriosis, cancer and osteoporosis. 2 The use of AAS by young sports practitioners has increased due to the need to obtain results in the short term, such as breaking records in competitions, and for muscle hypertrophy, either for aesthetic or bodybuilding purposes. 3,4 However, these substances are known to be associated with adverse effects, including acne, testicular atrophy, mood changes, water retention and gynecomastia. The prevalence of use of AAS varies across geographic regions, ranging from 0.2% in Asia, 4.8% in South America, reaching 21.7% in the Middle East. 5In addition, biochemical changes induced by AAS can promote changes in the lipid profile, characterized by a

Non-alcoholic fatty liver disease is growing in worldwide prevalence and thus, is expected to have a higher number of NAFLD-related hepatocellular carcinoma (HCC) in the following years. This review describes the risk factors associated with HCC in NAFLD-patients. The presence of liver cirrhosis is the preponderant one. Male gender, PNPLA3 variants, diabetes, and obesity also appear to predispose to the development of HCC, even in non-cirrhotic subjects. Thus far, intensive lifestyle modifications, including glycemic control, and obesity treatment, are effective therapies for NAFLD/ non-alcoholic steatohepatitis and, therefore, probably, also for HCC. Some drugs that aimed at decreasing inflammatory activity and fibrosis, as well as obesity, were studied. Other data have suggested the possibility of HCC chemoprevention. So far, however, there is no definitive evidence for the routine utilization of these drugs. We hope, in the future, to be able to profile patients at higher risk of NAFLD-HCC and outline strategies for early diagnosis and prevention.

Bone tumors arising from the foot and ankle are relatively rare. The correct diagnosis is commonly ignored, and the potential risk of these tumors is often underestimated. Due to the rarity and particularities of the presentation, there is a lack of evidence on epidemiological data related to the distribution of bone tumors of the foot and ankle by age group, gender and location. As far as we know, no systematic review or meta-analysis was performed on the grouping of bone tumors in this region. The objective of this protocol is to design a systematic review of the evidence to verify these data. Systematic literature research will be carried out in the PubMed/MEDLINE, Embase (by CAPES JOURNALS) and LILACS databases, without time and linguistic restrictions in the search strategy. The reference lists of the included articles will be evaluated to detect unidentified studies. Two evaluators will independently select the articles, extract the data and assess the risk of bias in the selected studies. If applicable, meta-analysis will be carried out, extracting data for the number of events and total patients to perform proportion meta-analysis using the R software, with the "meta" package (version 4.9–6), the "metaprop function" for aspect ratio data. The results of this review will be added to the existing literature, providing convincing information on the epidemiology of these neoplasms, important data that will support future research and help in possible diagnostic, preventive and therapeutic measures. This protocol will provide a reliable theoretical basis for the research that will follow.

Background Advanced chronic liver disease (ACLD) patients are usually malnourished, and both conditions in combination increase the likelihood of unfavourable clinical outcomes. Handgrip strength (HGS) has been suggested as a relevant parameter for nutritional assessment and predictor of adverse clinical outcomes in ACLD. However, the HGS cut‐off values for ACLD patients have not yet been reliably established. The aims of this study were to preliminarily identify HGS reference values in a sample population of ACLD male patients and to assess their association with survival over a 12‐month follow‐up period. Methods This was a prospective observational study with preliminary analysis of outpatients and inpatients. A total of 185 male patients with a medical diagnosis of ACLD met the inclusion criteria and were invited to participate in the study. The physiological variation in muscle strength related to the age of the individuals included in the study was considered to obtain cut‐off values. Results After categorising HGS by age group (adults: 18–60 years; elderly: ≥60 years), the reference values obtained were 32.5 kg for the adults and 16.5 kg for the elderly. During the 12‐month follow‐up, 20.5% of the patients died, and 76.3% of those had been identified with reduced HGS. Conclusions Patients with adequate HGS showed significantly higher 12‐month survival than those with reduced HGS within the same period. Our findings show that HGS is an important predictive parameter for clinical and nutritional follow‐up in ACLD male patients.