Anti-inflamatórios não esteroides afetam as respostas ao treinamento resistido em indivíduos idosos e de meia-idade?

Abstract

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most popular drugs in the world for treating pain and inflammation. Although the long-term use of NSAIDs is associated with adverse renal, cardiovascular, hepatic, and other effects, it has also been suggested that may cause impairing neuromuscular adaptations promoted by exercise. Objective: The objective of this systematic review was to compare the effects of NSAIDs use in neuromuscular adaptations, such as hypertrophy and muscle strength in middle-aged and elderly practitioners of resistance training. Methods: The databases included Bireme, Pubmed e Science Direct. Meta-analyses were conducted using the robust variance estimation of correlated effects with small-sample adjustments. Results: Six studies were included for meta-analytical analysis. No statistical differences were found for hypertrophy (ES: 0.000531 ± 0.0424, 95%CI: -0.123 – 0.124; P = 0.991) and muscle strength (ES: 0.323 ± 0.213, 95% CI: -0.417 – 1.06; P = 0.258). Conclusion: The findings of this review do not support the hypothesis that the use of NSAIDs combined with resistance exercise negatively influences the hypertrophy and muscle strength.Keywords: non-steroidal anti-inflammatory agents, resistance training, hypertrophy, muscle strength, aged.

No Pain, No Gain? Examining the Influence of Ibuprofen Consumption on Muscle Hypertrophy

“…Strength and Conditioning Journal | www.nsca-scj.com reported a pooled effect size of 0.0 nested within a narrow 95% confidence interval of 20.12 to 0.12 (24). Because effect sizes lower than 0.20 are often considered "trivial," these findings suggest that even if there is an actual effect of ibuprofen use-in either direction-it would most likely be practically negligible (4,24).…”

“…Specifically, these data have not yet been replicated, given that all other studies that explored the effects of ibuprofen ingestion did not report a differential effect on muscle hypertrophy compared with placebo (Table 1). Moreover, meta-analytical data are now also available that explored the effects of ibuprofen versus placebo on muscle hypertrophy in middle-aged and older adults (older than 50 years) (24). When considering the whole body of evidence, this meta-analysis reported a pooled effect size of 0.0 nested within a narrow 95% confidence interval of −0.12 to 0.12 (24).…”

“…Moreover, meta-analytical data are now also available that explored the effects of ibuprofen versus placebo on muscle hypertrophy in middle-aged and older adults (older than 50 years) (24). When considering the whole body of evidence, this meta-analysis reported a pooled effect size of 0.0 nested within a narrow 95% confidence interval of −0.12 to 0.12 (24). Because effect sizes lower than 0.20 are often considered “trivial,” these findings suggest that even if there is an actual effect of ibuprofen use—in either direction—it would most likely be practically negligible (4,24).…”

“…Strength and Conditioning Journal | www.nsca-scj.com reported a pooled effect size of 0.0 nested within a narrow 95% confidence interval of 20.12 to 0.12 (24). Because effect sizes lower than 0.20 are often considered "trivial," these findings suggest that even if there is an actual effect of ibuprofen use-in either direction-it would most likely be practically negligible (4,24). Included studies varied in several methodological factors such as ibuprofen dose, duration of the training interventions, and tool used to evaluate gains in muscle size (e.g., magnetic resonance imaging, dual-energy x-ray absorptiometry, and ultrasound).…”